Table 1.
Relevant results of blood analyses.
| Reference range | Baseline (d − 4) | Vacc1 (d0) | 3d post-Vacc1 (d3) | 6d post-Vacc1 (d6) | Recovery (d17) | Vacc2 (d35) | 3d post-Vacc2 (d38) | 6d post-Vacc2 (d41) | |
|---|---|---|---|---|---|---|---|---|---|
| Clozapine (ng/ml) | 350–600 | 383 | 426 | 589 | 387 | 401 | 571 | 854 | 577 |
| Norclozapine (ng/ml) | — | 197 | 218 | 277 | 195 | 239 | 325 | 411 | 290 |
| Clozapine blood-dosage ratio ((ng/ml)/(mg/day)) | 0.6–1.2 | 1.28 | 1.42 | 1.96 | 1.29 | 1.15 ∗ | 1.52 ∗ | 2.28 | 1.27 |
| Leukocytes (/nl) | 3.5–10 | 6.93 | — | 4.85 | — | 7.2 | — | 4.92 ∗∗ | — |
| Neutrophils (%) | 43–75 | 54.5 | — | 58.7 | — | 66.9 | — | 52.9 ∗∗ | — |
| CRP (mg/l) | <5 | 3.5 | — | 12 | — | 1.8 | — | 14 ∗∗ | — |
Bold letters indicate values above reference. d, day; Vacc1, first vaccination; Vacc 2, second vaccination. ∗Indicates the absence of a steady state since the clozapine dosage has been changed in the previous 5 days. ∗∗Indicates data from 4 days post Vacc2 (d39) since no routine was obtained from d38.