Table 1. Related Parameters of Identification and Quantitation of Proteins.

item	value
enzyme	trypsin
max missed cleavages	2
fixed modifications	carbamidomethyl (C) TMT 6/10/16 plex (N-term), TMT 6/10/16 plex (K)
variable modifications	oxidation (M)
peptide mass tolerance	±20 ppm
fragment mass tolerance	0.1 Da
database	Swissprot_Homo_sapiens_20395_20210106.fasta
database pattern	decoy
peptide FDR	≤0.01
protein quantification	the protein ratios were calculated as the median of only unique peptides of the protein.