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. 2023 Dec 5;23:384. doi: 10.1186/s12866-023-03091-6

Table 3.

Effect of glycerol supplementation and L. reuteri PTA5_F13 on the metabolic activity of chicken cecal microbiota during in vitro F3

Reactors Mean metabolite concentration (mM) ± SD Ratios of Total SCFAs (%)
Acetate Butyrate Propionate Succinate Valerate 1,3 – PDO Total BCFAs Total metabolites Acetate Butyrate Propionate
Control
 Pre-treatment 83.9 ± 1.9 48.7 ± 0.5 11.7 ± 0.6 2.4 ± 1.5 9.7 ± 0.5 0.0 ± 0.0 15.0 ± 0.3 171.1 ± 4.0 58.1 ± 0.2 33.7 ± 0.6 8.1 ± 0.2
 Treatment 76.5 ± 1.1 46.4 ± 0.6 10.7 ± 0.3 1.1 ± 0.1 9.0 ± 0.1 0.0 ± 0.0 16.6 ± 0.2 160.7 ± 1.6 57.2 ± 0.1 34.7 ± 0.3 8.0 ± 0.2
 Treatment – Pre treatment - 7.4 - 2.2 - 1.0 - 1.3 - 0.6  + 1.6 - 10.8 - 0.8  + 0.9 0.1
P value 0.0045 0.0092 0.0609 0.1942 0.0769 0.0009 0.0123 0.0091 0.0611 0.6745
100G
 Pre-treatment 95.3 ± 3.0 44.9 ± 1.4 10.3 ± 1.4 0.7 ± 0.1 9.4 ± 0.2 0.0 ± 0.0 14.9 ± 0.4 175.8 ± 6.1 63.3 ± 0.5 29.8 ± 0.2 6.8 ± 0.7
 Treatment 63.2 ± 1.0 83.1 ± 4.1 5.9 ± 0.8 2.1 ± 1.8 8.1 ± 0.8 22.3 ± 7.4 16.1 ± 0.6 178.6 ± 1.8 41.5 ± 1.0 54.5 ± 1.5 3.9 ± 0.5
 Treatment – Pre treatment - 32.0  + 38.0 - 4.3  + 1.3 - 1.3  + 22.3  + 1.0  + 2.8 - 21.8  + 24.7 - 2.9
P value 0.00006 0.0001 0.0107 0.1114 0.0511 0.0063 0.0638 0.4868 0.000005 0.00001 0.0055
Lbr
 Pre-treatment 98.5 ± 2.6 43.7 ± 1.9 13.8 ± 0.5 1.0 ± 0.1 9.6 ± 0.5 0.0 ± 0.0 17.9 ± 0.5 184.6 ± 5.9 63.1 ± 0.3 28.0 ± 0.3 8.8 ± 0.1
 Treatment 101.3 ± 0.9 36.3 ± 2.2 15.4 ± 1.7 1.0 ± 0.1 8.3 ± 0.3 0.0 ± 0.0 17.0 ± 0.7 179.8 ± 2.3 66.1 ± 0.2 23.7 ± 1.3 10.0 ± 1.2
 Treatment – Pre treatment  + 2.8 - 7.3  + 1.6 - - 1.2 - 0.8 - 4.8  + 3.0  + 4.2  + 1.2
P value 0.1443 0.0124 0.1853 0.5772 0.0220 0.1619 0.2624 0.0002 0.0050 0.1422
Lbr-100G
 Pre-treatment 94.3 ± 3.7 46.3 ± 1.0 10.5 ± 2.4 3.3 ± 1.8 9.4 ± 0.8 0.0 ± 0.0 13.7 ± 2.5 177.7 ± 6.1 62.4 ± 1.9 30.6 ± 1.2 6.9 ± 1.5
 Treatment 69.6 ± 4.8 86.7 ± 5.2 5.4 ± 0.8 5.5 ± 1.2 6.4 ± 1.1 61.4 ± 10.7 14.6 ± 3.3 187.9 ± 5.4 43.0 ± 3.0 53.6 ± 3.2 3.3 ± 0.4
 Treatment – Pre treatment - 24.0  + 40.4 - 5.1  + 2.3 - 3.1  + 61.4  + 0.5  + 10.1 - 19.3  + 22.9 - 3.6
P value 0.0021 0.0001 0.0256 0.1529 0.0170 0.0047 0.8546 0.0986 0.0007 0.00032 0.0182

Data are means ± SD for the last 3 days of each treatment period. Delta corresponds the difference between treatment and pre-treatment. P value is calculated for the pairwise comparison of the last 3 days of treatment and pre-treatment periods within a reactor by unpaired t-test. CR, Control reactor; 100G, 100 mM glycerol; Lbr, L. reuteri PTA5_F13; Lbr-100G, L. reuteri PTA5_F13 and 100 mM glycerol