Table 4.

Mutant frequencies in the transgenic mouse gene mutation test

Target genes	Chemicals	Doses	Mutant Frequency (×10−6)
			Spleen	Liver	Colon	Forestomach
lacZ	Olive oil	10 mL/kg	40.4 ± 24.5	62.9 ± 10.1	82.5 ± 76.6	30.8 ± 2.7
	AF-2	120 mg/kg	30.4 ± 4.3	66.1 ± 8.1	39.9 ± 5.4	57.0 ± 30.7
	DBP	6 mg/kg	535.5 ± 230.0	280.7 ± 24.6	189.7 ± 40.1	220.4 ± 47.8
cII	Olive oil	10 mL/kg	18.1 ± 12.5	31.1 ± 14.6	77.4 ± 65.8	42.6 ± 32.0
	AF-2	120 mg/kg	39.7 ± 22.9	45.9 ± 32.0	31.6 ± 10.6	29.8 ± 12.9
	DBP	6 mg/kg	348.9 ± 175.0	77.3 ± 28.4	123.7 ± 37.9	99.7 ± 15.4

Administration was carried out intraperitoneally for olive oil and DBP and orally for AF-2

See Supplementary Data for detailed figures on which the calculations are based