Table 1.
Effect of BBR on FtfLs from different strains. The inhibition of BBR on FtfLs from S. faecalis, L. reuteri, L. acidophilus, and L. fermentum is not determined due to non-detectable enzymatic activity; “ns” means no significance, representing that FtfL from this strain is not inhibited by BBR
| Strain | ftfl Gene ID | Inhibited by BBR (IC50) |
|---|---|---|
| CRC pathogens | ||
| Peptostreptococcus anaerobius | 79,842,341 | 62.3 ± 10 μM |
| Fusobacterium nucleatum | 45,633,862 | 106.2 ± 27.0 μM |
| Clostridium symbiosum | 57,969,199 | 128.9 ± 17.1 μM |
| Lactococcus lactis | 69,713,002 | 118.1 ± 18.5 μM |
| Streptococcus faecalis | 60,894,021 | / |
| Colitis pathogens | ||
| Bacteroides fragilis | 66,328,797 | 105.1 ± 69.8 μM |
| Clostridioides difficile | 66,353,223 | 158.0 ± 68.7 μM |
| Vibrio cholerae | 69,721,326 | 129.6 ± 12.3 μM |
| Clostridium perfringens | 69,450,453 | 104.9 ± 3.15 μM |
| Nonpathogenic bacteria | ||
| Clostridium ljungdahlii | 45,181,033 | 83.8 ± 10 μM |
| Clostridium sporogenes | 69,424,169 | ns |
| Parabacteroides distasonis | 57,237,971 | > 200.0 μM |
| Ruminococcus obeum | 15,206,023 | 100.1 ± 3.26 μM |
| Probiotics | ||
| Lactobacillus plantarum | 57,025,392 | > 200.0 μM |
| Lactobacillus reuteri | 69,707,752 | / |
| Lactobacillus acidophilus | 56,943,130 | / |
| Lactobacillus fermentum | 12,456,081 | / |