Table 2.
Long-term outcomes after resection relative to PACE risk score
| Variable | Total | PACE low-risk | PACE intermediate-risk | PACE high-risk | P |
|---|---|---|---|---|---|
| Median RFS, months | 37.4 (35.0, 42.2) | 47.5 (43.5, 57.3) | 27.8 (24.8, 34.3) | 7.7 (6.0, 10.8) | < 0.001 * |
| 1-year RFS | 72.0 (70.4, 73.8) | 79.1 (77.2, 81.1) | 64.4 (61.4, 67.6) | 40.0 (32.5, 49.1) | |
| 3-year RFS | 51.5 (49.4, 53.6) | 57.3 (54.7, 60.0) | 45.5 (42.0, 49.1) | 23.0 (162, 32.7) | |
| 5-year RFS | 41.2 (38.6, 43.9) | 44.9 (41.5, 48.5) | 38.4 (34.4, 43.0) | 18.0 (11.5, 28.3) | |
| Recurrence, n, % | 1272 (45.9%) | 684 (41.1%) | 485 (50.6%) | 103 (70.1%) | < 0.001 # |
| Recurrence Timing | |||||
| Early recurrence, ≤ 24 months | 998 (78.5%) | 502 (73.4%) | 403 (82.2%) | 93 (90.3%) | < 0.001 # |
| Late recurrence, > 24 months | 274 (21.5%) | 182 (26.6%) | 82 (17.8%) | 10 (9.7%) | |
| Recurrence pattern | |||||
| Intrahepatic | 1052 (82.7%) | 592 (86.5%) | 376 (77.5%) | 84 (81.6%) | 0.001 # |
| Extrahepatic | 72 (5.7%) | 25 (3.7%) | 40 (8.3%) | 7 (6.8%) | |
| Both | 148 (11.6%) | 67 (9.8%) | 69 (14.2%) | 12 (11.6%) | |
| Death, n, % | 947 (34.2%) | 464 (27.9%) | 387 (40.4%) | 96 (65.3%) | < 0.001 # |
| Median OS, months | 60.4 (59.4, 61.1) | 65.5 (61.3, 75.4) | 48.7 (48.1, 59.2) | 19.9 (14.7, 26.6) | < 0.001 * |
| 1-year OS | 89.7 (88.6, 90.9) | 93.5 (92.3, 94.7) | 86.4 (84.3,88.7) | 68.8 (61.6, 76.9) | |
| 3-year OS | 68.2 (66.2, 70.1) | 76.3 (74.0, 78.6) | 59.5 (56.0, 63.1) | 32.5 (24.9, 42.4) | |
| 5-year OS | 52.1 (49.4, 54.9) | 59.6 (56.1, 63.2) | 43.9 (39.2, 49.0) | 20.6 (13.5, 31.5) | |
Abbreviations: PACE, Prognostic implications of Alpha-fetoprotein and C-reactive protein Elevation; RFS, recurrence-free survival; OS, overall survival
*Tested by log-rank test; #Tested by χ2 test