Table 3.

Univariable and multivariable Cox regression analyses on risk factors of overall survival

Variables	HR comparison	UV HR (95% CI)	UV P	MV HR (95% CI)	MV P
Age	> 55 vs. ≤55 years	0.867 (0.762–0.986)	0.030	NS	0.981
Gender	Male vs. female	1.024 (0.856–1.225)	0.795
Diabetes	Present vs. absent	1.061 (0.856–1.316)	0.588
Hypertension	Present vs. absent	0.963 (0.814–1.140)	0.663
HBsAg	Positive vs. negative	1.113 (0.922–1.343)	0.266
HCVAb	Positive vs. negative	0.873 (0.494–1.544)	0.641
Child-Pugh	B vs. A	1.569 (1.261–1.952)	< 0.001	1.377 (1.101–1.723)	0.005
Cirrhosis	Present vs. absent	0.862 (0.756–0.981)	0.025	NS	0.126
PLT	< 100 vs. ≥100 109/L	1.076 (0.910–1.273)	0.389
Tumor number	Multiple vs. solitary	2.437 (2.002–2.966)	< 0.001	1.420 (1.209–1.668)	< 0.001
Tumor diameter	≥ 10 vs. <10 cm	1.114 (1.099–1.129)	< 0.001	1.527 (1.283–1.817)	< 0.001
Tumor differentiation	III/IV vs. I/II	2.279 (1.784–2.910)	< 0.001	1.619 (1.253–2.092)	< 0.001
Tumor capsule	Incomplete vs. complete	1.397 (1.148–1.699)	0.001	1.065 (0.869–1.304)	< 0.001
Tumor capsule	None vs. complete	1.986 (1.589–2.482)	< 0.001	1.491 (1.183–1.881)	< 0.001
Satellite nodules	Presence vs. absence	1.861 (1.635–2.118)	< 0.001	1.236 (1.059–1.443)	< 0.001
Intraoperative blood loss	≥ 800 ml vs. <800 ml	2.163 (1.724–2.713)	< 0.001	1.334 (1.043–1.706)	0.021
Anatomical hepatectomy	Yes vs. no	0.837 (0.726–0.964)	0.014	NS	0.511
Resection margin	≥ 1 cm vs. <1 cm	0.602 (0.525–0.689)	< 0.001	0.699 (0.595–0.821)	< 0.001
PACE risk score	intermediate-risk vs. low-risk	1.725 (1.506–1.975)	< 0.001	1.413 (1.226–1.628)	< 0.001
PACE risk score	high-risk vs. low-risk	3.974 (3.187–4.956)	< 0.001	2.425 (1.891–3.109)	< 0.001

Abbreviations: PACE, Prognostic implications of Alpha-fetoprotein and C-reactive protein Elevation; HBV, hepatitis B virus; HCV, hepatitis C virus; PLT, platelet; HR, hazard ratio; CI, confidence interval; UV univariable

Schoenfeld residuals test for proportional hazards assumption: met (P = 0.102)