Table 4.

Univariable and multivariable Cox regression analyses on risk factors of recurrence-free survival

Variables	HR comparison	UV HR (95% CI)	UV P	MV HR (95% CI)	MV P
Age	> 55 vs. ≤55 years	0.964 (0.863–1.076)	0.512
Gender	Male vs. female	1.044 (0.895–1.218)	0.582
Diabetes	Present vs. absent	0.989 (0.817–1.197)	0.910
Hypertension	Present vs. absent	0.887 (0.767–1.026)	0.107
HBsAg	Positive vs. negative	1.355 (1.142–1.608)	0.001	NS	0.527
HCVAb	Positive vs. negative	0.840 (0.513–1.376)	0.490
Child-Pugh	B vs. A	1.318 (1.078–1.611)	0.007	1.325 (1.060–1.655)	0.013
Cirrhosis	Present vs. absent	1.078 (0.961–1.210)	0.199
PLT	< 100 vs. ≥100 109/L	0.981 (0.844–1.140)	0.801
Tumor number	Multiple vs. solitary	2.211 (1.840–2.656)	< 0.001	1.379 (1.175–1.620)	< 0.001
Tumor diameter	≥ 10 vs. <10 cm	2.163 (1.896–2.468)	< 0.001	1.606 (1.352–1.909)	< 0.001
Tumor differentiation	III/IV vs. I/II	1.399 (1.166–1.678)	< 0.001	1.681 (1.303–2.169)	< 0.001
Tumor capsule	Incomplete vs. complete	1.214 (1.035–1.424)	0.017	NS	0.511
Tumor capsule	None vs. complete	1.428 (1.180–1.728)	< 0.001	1.601 (1.271–2.017)	< 0.001
Satellite nodules	Presence vs. absence	1.396 (1.250–1.560)	< 0.001	1.396 (1.206–1.617)	< 0.001
Intraoperative blood loss	≥ 800 ml vs. <800 ml	1.975 (1.599–2.440)	< 0.001	1.312 (1.026–1.678)	0.031
Anatomical hepatectomy	Yes vs. no	0.771 (0.682–0.872)	< 0.001	NS	0.427
Resection margin	≥ 1 cm vs. <1 cm	0.678 (0.605–0.761)	< 0.001	0.697 (0.592–0.819)	< 0.001
PACE risk score	intermediate-risk vs. low-risk	1.468 (1.306–1.649)	< 0.001	1.433 (1.244–1.650)	< 0.001
PACE risk score	high-risk vs. low-risk	3.065 (2.490–3.774)	< 0.001	2.517 (1.964–3.225)	< 0.001

Abbreviations: PACE, Prognostic implications of Alpha-fetoprotein and C-reactive protein Elevation; HBV, hepatitis B virus; HCV, hepatitis C virus; PLT, platelet; MVI, microvascular invasion; HR, hazard ratio; CI, confidence interval; UV univariable

Schoenfeld residuals test for proportional hazards assumption: met (P = 0.139)