Table 2.

The function of the top 50 DEGs in HCT116 cells treated with Fr. 12. DEGs

Rank	RefSeq_ID	Gene symbol	Gene function to human cancer cell line	Reference
6	XM_024451436	HSPBP1	Inhibition of cell proliferation in breast cancer by overexpression.	[21]
11	XM_006720559	NUSAP1	Inhibition of cell proliferation, and induction of apoptosis in colon cancer by knockdown.	[22]
12	XM_047440908	SETD4	Inhibition of cell proliferation and cell cycle at G1/S phase in breast cancer by knockdown.	[23]
14	XM_017009117	BTNL9	Inhibition of cell proliferation, colonization and cell cycle at G2/M phase, and induction of apoptosis in breast cancer.	[24]
18	NM_001369604	ST7	Overexpression in cell cycle arrest, and decreased expression in cell division.	[25]
19	XM_047434283	BANP	Inhibition of cell cycle and proliferation in breast cancer and colon cancer.	[26, 27]
22	XM_047447884	SASS6	Inhibition of cell cycle at G2/M phase and proliferation, induction of apoptosis in breast cancer and colon cancer by knockdown.	[28, 29]
24	NM_001350759	C1orf109	Inhibition of cell viability in breast cancer.	[30]
30	NM_080685	PTPN13	Inhibition of proliferation and colonization, and induction of apoptosis in renal cancer by increased expression.	[31]
34	XM_047443470	GPAT2	Inhibition of proliferation, and induction of apoptosis in breast cancer by knockdown.	[32]
38	NM_001077527	JRK	Inhibition of proliferation in breast cancer and colon cancer.	[33]
39	XM_047443471	GPAT2	Inhibition of proliferation, and induction of apoptosis in breast cancer by knockdown.	[32]
41	XM_047436491	TNRC6C	Inhibition of proliferation, and induction of apoptosis in papillary thyroid cancer by overexpression.	[34]
43	XM_047429511	ZNF84	Induction of proliferation by knockdown.	[35]
45	NM_021908	ST7	Inhibition of colonization and proliferation in prostate cancer and breast cancer.	[25]
46	NM_001346258	USP28	Induction of apoptosis in lung cancer by knockdown, and promotion of cell cycle and inhibition of apoptosis in pancreatic cancer by overexpression.	[36, 37]
47	NM_001369557	RPL17	Induction of apoptosis in colon cancer by knockdown.	[38]
48	NM_001281779	ZMYND8	Promotion of proliferation, migration and invasion in breast cancer and liver cancer.	[39, 40]
49	XM_005265382	SEMA3F	Inhibition of proliferation in oral cancer.	[41]