Table 1.
Hematology results from cynomolgus monkeys fasted for different time periods after a 14-day acclimatization period of one meal/day (feeding regimen 1).
| Analytes | Sex | Fasting, hours | |||
|---|---|---|---|---|---|
| 4 | 8 | 12 | 20 | ||
| WBC, ×103/µL | Males | 14.53 ± 2.8 | 16.71 ± 3.0* | 13.43 ± 3.1 | 11.89 ± 2.9** |
| Females | 15.34 ± 4.6 | 20.28 ± 5.8* | 15.61 ± 3.8** | 13.29 ± 3.9 | |
| NEUT, ×103/µL | Males | 3.96 ± 1.2 | 5.81 ± 1.1** | 4.61 ± 1.5 | 3.26 ± 1.4 |
| Females | 6.72 ± 2.7 | 10.28 ± 4.1** | 8.02 ± 4.4 | 7.33 ± 3.3 | |
| LYMPH, ×103/µL | Males | 9.59 ± 2.9 | 9.96 ± 2.9 | 12.06 ± 3.6* | 7.81 ± 2.6* |
| Females | 7.61 ± 2.8 | 8.93 ± 2.93 | 9.25 ± 3.8 | 5.27 ± 2.9* | |
| MONO, ×103/µL | Males | 0.43 ± 0.1 | 0.50 ± 0.14 | 0.63 ± 0.2** | 0.43 ± 0.1 |
| Females | 0.52 ± 0.2 | 0.65 ± 0.25 | 0.80 ± 0.3** | 0.42 ± 0.2 | |
| EOS, ×103/µL | Males | 0.34 ± 0.4 | 0.25 ± 0.23 | 0.36 ± 0.3 | 0.24 ± 0.2 |
| Females | 0.29 ± 0.4 | 0.21 ± 0.3 | 0.30 ± 0.4 | 0.15 ± 0.3 | |
| BASO, ×103/µL | Males | 0.11 ± 0.07 | 0.08 ± 0.03 | 0.09 ± 0.04 | 0.05 ± 0.02** |
| Females | 0.10 ± 0.08 | 0.09 ± 0.05 | 0.08 ± 0.04 | 0.04 ± 0.02* | |
| LUC, ×103/µL | Males | 0.10 ± 0.04 | 0.11 ± 0.04 | 0.15 ± 0.07** | 0.09 ± 0.04 |
| Females | 0.10 ± 0.06 | 0.13 ± 0.06 | 0.15 ± 0.08 | 0.07 ± 0.04 | |
| HCT, % | Males | 45.27 ± 2.1 | 43.80 ± 1.8* | 43.40 ± 2.1** | 42.90 ± 2.2** |
| Females | 43.43 ± 2.4 | 43.17 ± 3.1 | 41.72 ± 2.7 | 40.45 ± 2.8** | |
| RBC, ×106/µL | Males | 5.85 ± 0.2 | 5.72 ± 0.3 | 5.68 ± 0.3* | 5.64 ± 0.3* |
| Females | 5.59 ± 0.3 | 5.50 ± 0.3 | 5.42 ± 0.3 | 5.26 ± 0.3* | |
| HGB, ×103/µL | Males | 13.54 ± 0.6 | 13.17 ± 0.6 | 13.03 ± 0.6* | 12.96 ± 0.7** |
| Females | 12.68 ± 0.5 | 12.44 ± 0.6 | 12.23 ± 06* | 11.91 ± 0.6** | |
| RETIC, ×103/µL | Males | 52.96 ± 10.6 | 53.42 ± 14.5 | 54.43 ± 13.7 | 52.01 ± 15.9 |
| Females | 55.01 ± 24.2 | 58.37 ± 23.3 | 57.47 ± 21.8 | 58.43 ± 22.2 | |
| RDW, % | Males | 13.10 ± 0.9 | 13.14 ± 1.0 | 13.23 ± 1.0 | 13.30 ± 1.0 |
| Females | 12.55 ± 1.1 | 12.62 ± 1.3 | 12.65 ± 1.3 | 12.77 ± 1.3 | |
| MCV, fL | Males | 77.40 ± 3.5 | 76.69 ± 3.5 | 76.51 ± 3.6 | 76.18 ± 3.7 |
| Females | 78.05 ± 6.7 | 78.88 ± 7.8 | 77.21 ± 7.0 | 77.14 ± 7.2 | |
| MCH, pg | Males | 23.15 ± 1.0 | 23.03 ± 0.9 | 22.95 ± 0.9 | 23.00 ± 1.0 |
| Females | 22.81 ± 1.9 | 22.74 ± 2.0 | 22.67 ± 1.9 | 22.75 ± 2.1 | |
| MCHC, g/dL | Males | 29.95 ± 1.6 | 30.08 ± 1.3 | 30.02 ± 1.4 | 30.23 ± 1.5 |
| Females | 29.27 ± 1.7 | 28.90 ± 1.9 | 29.42 ± 1.8 | 29.53 ± 1.8 | |
| PLT, ×103/µL | Males | 416.15 ± 89.7 | 399.05 ± 87.3 | 392.85 ± 89.9 | 408.35 ± 83.6 |
| Females | 441.53 ± 89.6 | 428.33 ± 91.0 | 429.33 ± 93.2 | 446.33 ± 91.3 | |
| MPV, fL | Males | 9.00 ± 1.3 | 8.86 ± 1.3 | 8.70 ± 1.2 | 8.91 ± 1.2 |
| Females | 8.55 ± 0.7 | 8.64 ± 0.8 | 8.55 ± 0.8 | 8.39 ± 0.7 | |
Abbreviations: BASO, absolute basophil counts; EOS, absolute eosinophil counts; HCT, hematocrit; HGB, hemoglobin; LUC, large unclassified cell counts; LYMPH, absolute lymphocyte counts; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean corpuscular volume; MONO, absolute monocyte counts; MPV, mean platelet volume; NEUT, absolute neutrophil counts; PLT, platelet; RBC, red blood cell count; RDW, red cell width; RETIC, absolute reticulocyte counts; WBC, white blood cell count.
*
P < .05. **P < .01 relative to the 4-hour time point.