Table 2.
Hematology results from cynomolgus monkeys fasted for different time periods after a 14-day acclimatization period of two meals/day (feeding regimen 2).
| Analytes | Sex | Fasting, hours | |||
|---|---|---|---|---|---|
| 4 | 8 | 12 | 20 | ||
| WBC, ×103/µL | Males | 14.96 ± 3.0 | 16.96 ± 3.8 | 18.60 ± 4.0** | 11.32 ± 3.1** |
| Females | 14.42 ± 3.2 | 19.02 ± 3.5** | 18.01 ± 3.2 | 12.75 ± 3.9 | |
| NEUT, ×103/µL | Males | 4.82 ± 1.9 | 6.42 ± 1.8** | 5.73 ± 1.7 | 3.83 ± 1.5 |
| Females | 5.90 ± 1.6 | 9.16 ± 2.2** | 7.14 ± 1.9 | 6.99 ± 3.2 | |
| LYMPH, ×103/µL | Males | 9.24 ± 3.3 | 9.61 ± 3.2 | 11.61 ± 3.4* | 6.79 ± 2.3** |
| Females | 7.43 ± 2.3 | 8.76 ± 2.6 | 9.46 ± 2.8* | 5.08 ± 2.5* | |
| MONO, ×103/µL | Males | 0.43 ± 0.1 | 0.50 ± 0.2 | 0.68 ± 0.2** | 0.38 ± 0.1 |
| Females | 0.51 ± 0.2 | 0.62 ± 0.3 | 0.78 ± 0.2** | 0.42 ± 0.2 | |
| EOS, ×103/µL | Males | 0.26 ± 0.2 | 0.23 ± 0.2 | 0.34 ± 0.2 | 0.20 ± 0.2 |
| Females | 0.35 ± 0.3 | 0.25 ± 0.2 | 0.38 ± 0.4 | 0.15 ± 0.2 | |
| BASO, ×103/µL | Males | 0.10 ± 0.05 | 0.08 ± 0.04 | 0.10 ± 0.05 | 0.05 ± 0.03** |
| Females | 0.10 ± 0.05 | 0.09 ± 0.07 | 0.09 ± 0.07 | 0.05 ± 0.06* | |
| LUC, ×103/µL | Males | 0.10 ± 0.05 | 0.11 ± 0.05 | 0.14 ± 0.06* | 0.08 ± 0.03 |
| Females | 0.07 ± 0.02 | 0.09 ± 0.03 | 0.09 ± 0.02 | 0.05 ± 0.01* | |
| HCT, % | Males | 44.76 ± 2.0 | 43.01 ± 2.3* | 42.47 ± 2.0** | 42.19 ± 2.1** |
| Females | 43.55 ± 2.2 | 42.85 ± 2.5 | 41.56 ± 2.5* | 40.71 ± 2.7** | |
| RBC, ×106/µL | Males | 5.78 ± 0.3 | 5.60 ± 0.3 | 5.55 ± 0.3* | 5.53 ± 0.3* |
| Females | 5.60 ± 0.4 | 5.50 ± 0.3 | 5.42 ± 0.3 | 5.31 ± 0.3* | |
| HGB, ×103/µL | Males | 13.38 ± 0.8 | 12.97 ± 0.8 | 12.87 ± 0.7* | 12.68 ± 0.7** |
| Females | 12.75 ± 0.7 | 12.42 ± 0.5 | 12.24 ± 0.6* | 11.97 ± 0.6** | |
| RETIC, ×103/µL | Males | 62.50 ± 29.3 | 58.55 ± 31.1 | 58.46 ± 28.0 | 59.29 ± 30.9 |
| Females | 53.02 ± 21.0 | 52.73 ± 17.3 | 53.69 ± 17.9 | 53.73 ± 18.9 | |
| RDW, % | Males | 13.07 ± 0.9 | 13.17 ± 0.9 | 13.24 ± 0.9 | 13.28 ± 0.9 |
| Females | 12.73 ± 1.1 | 12.73 ± 1.0 | 12.77 ± 1.0 | 12.90 ± 1.0 | |
| MCV, fL | Males | 77.50 ± 2.9 | 76.89 ± 3.8 | 76.63 ± 3.5 | 76.35 ± 3.8 |
| Females | 78.00 ± 5.3 | 78.08 ± 5.9 | 76.91 ± 5.1 | 76.81 ± 5.5 | |
| MCH, pg | Males | 23.13 ± 0.9 | 23.18 ± 1.0 | 23.20 ± 1.0 | 22.88 ± 1.0 |
| Females | 22.86 ± 2.0 | 22.71 ± 2.0 | 22.69 ± 2.0 | 22.61 ± 1.9 | |
| MCHC, g/dL | Males | 29.88 ± 1.2 | 30.14 ± 1.1 | 30.30 ± 1.1 | 30.02 ± 1.4 |
| Females | 29.29 ± 1.5 | 29.07 ± 1.8 | 29.48 ± 1.6 | 29.47 ± 1.7 | |
| PLT, ×103/µL | Males | 432.42 ± 110.5 | 415.65 ± 103.5 | 415.30 ± 109.7 | 430.85 ± 107.5 |
| Females | 444.07 ± 110.3 | 436.27 ± 107.7 | 434.67 ± 113.0 | 455.33 ± 122.7 | |
| MPV, fL | Males | 8.81 ± 1.1 | 8.76 ± 1.1 | 8.85 ± 1.4 | 8.58 ± 1.0 |
| Females | 8.68 ± 0.8 | 8.58 ± 0.7 | 8.47 ± 0.8 | 8.55 ± 0.6 | |
Abbreviations: BASO, absolute basophil counts; EOS, absolute eosinophil counts; HCT, hematocrit; HGB, hemoglobin; LUC, large unclassified cell counts; LYMPH, absolute lymphocyte counts; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean corpuscular volume; MONO, absolute monocyte counts; MPV, mean platelet volume; NEUT, absolute neutrophil counts; PLT, platelet; RBC, red blood cell count; RDW, red cell width; RETIC, absolute reticulocyte counts; WBC, white blood cell count.
*
P < .05. **P < .01 relative to the 4-hour time point.