Table 3.
Serum chemistry results from cynomolgus monkeys fasted for different time periods after a 14-day acclimatization period of one meal/day (feeding regimen 1).
| Analyte | Sex | Fasting, hours | |||
|---|---|---|---|---|---|
| 4 | 8 | 12 | 20 | ||
| TRIG, mg/dL | Males | 53.55 ± 28.5 | 53.25 ± 26.3 | 55.50 ± 19.6 | 46.55 ± 14.1 |
| Females | 66.80 ± 35.8 | 58.87 ± 25.6 | 63.87 ± 26.2 | 55.40 ± 13.5 | |
| CHOL, mg/dL | Males | 144.80 ± 19.5 | 145.90 ± 19.6 | 143.00 ± 20.0 | 141.45 ± 21.6 |
| Females | 150.47 ± 19.8 | 148.13 ± 20.6 | 142.93 ± 21.7 | 141.27 ± 20.8 | |
| GLU, mg/dL | Males | 85.55 ± 10.0 | 79.30 ± 14.4 | 83.25 ± 19.4 | 57.45 ± 12.4** |
| Females | 84.87 ± 20.6 | 73.00 ± 18.7 | 76.33 ± 29.2 | 63.80 ± 13.1** | |
| TP, g/dL | Males | 7.18 ± 0.3 | 7.16 ± 0.3 | 6.93 ± 0.4* | 6.92 ± 0.4* |
| Females | 7.28 ± 0.4 | 7.23 ± 0.4 | 6.99 ± 0.4 | 6.97 ± 0.4* | |
| ALB, g/dL | Males | 4.57 ± 0.2 | 4.60 ± 0.2 | 4.44 ± 0.2 | 4.42 ± 0.2* |
| Females | 4.23 ± 0.3 | 4.30 ± 0.2 | 4.11 ± 0.2 | 4.13 ± 0.2 | |
| GLOB, g/dL | Males | 2.61 ± 0.3 | 2.56 ± 0.3 | 2.49 ± 0.3 | 2.50 ± 0.3 |
| Females | 3.05 ± 0.2 | 2.93 ± 0.2 | 2.87 ± 0.3 | 2.85 ± 0.2* | |
| A: G Ratio | Males | 1.78 ± 0.3 | 1.84 ± 0.3 | 1.82 ± 0.3 | 1.80 ± 0.3 |
| Females | 1.39 ± 0.1 | 1.46 ± 0.1 | 1.43 ± 0.1 | 1.47 ± 0.1 | |
| CRP, mg/dL | Males | 0.47 ± 0.2 | 0.48 ± 0.2 | 0.57 ± 0.2 | 0.66 ± 0.3* |
| Females | 0.62 ± 0.3 | 0.56 ± 0.3 | 0.71 ± 0.3 | 0.85 ± 0.5 | |
| UN, mg/dL | Males | 26.60 ± 5.5 | 25.95 ± 4.8 | 26.50 ± 4.9 | 26.95 ± 4.9 |
| Females | 23.00 ± 4.5 | 23.67 ± 5.1 | 24.67 ± 5.3 | 25.47 ± 4.6 | |
| CREA, mg/dL | Males | 1.03 ± 0.1 | 1.03 ± 0.1 | 1.07 ± 0.1 | 1.05 ± 0.1 |
| Females | 1.03 ± 0.1 | 1.03 ± 0.1 | 1.03 ± 0.2 | 1.09 ± 0.2 | |
| PHOS, mg/dL | Males | 5.97 ± 1.0 | 6.43 ± 0.7 | 8.16 ± 0.7** | 8.25 ± 0.7** |
| Females | 5.08 ± 0.7 | 5.95 ± 1.0** | 7.08 ± 1.0** | 6.31 ± 1.0** | |
| Ca, mg/dL | Males | 11.22 ± 0.5 | 11.07 ± 0.4 | 11.20 ± 0.5 | 10.75 ± 0.4** |
| Females | 10.99 ± 0.8 | 11.23 ± 0.8 | 11.00 ± 0.7 | 10.43 ± 0.4* | |
| TBIL, mg/dL | Males | 0.12 ± 0.04 | 0.11 ± 0.03 | 0.12 ± 0.04* | 0.21 ± 0.09** |
| Females | 0.10 ± 0.00 | 0.13 ± 0.05 | 0.16 ± 0.06 | 0.27 ± 0.12** | |
| ALP, U/L | Males | 629.55 ± 140.2 | 628.40 ± 141.9 | 621.40 ± 139.6 | 625.80 ± 145.4 |
| Females | 344.87 ± 104.3 | 351.00 ± 103.7 | 343.47 ± 105.6 | 345.87 ± 104.5 | |
| GGT, U/L | Males | 87.80 ± 30.4 | 88.00 ± 30.0 | 84.90 ± 29.1 | 84.50 ± 29.0 |
| Females | 49.67 ± 15.0 | 50.14 ± 14.4 | 48.20 ± 15.0 | 47.33 ± 14.1 | |
| ALT, U/L | Males | 45.95 ± 14.6 | 47.30 ± 13.2 | 47.15 ± 11.9 | 47.40 ± 12.2 |
| Females | 40.40 ± 15.7 | 41.87 ± 16.5 | 41.13 ± 15.5 | 42.53 ± 16.5 | |
| AST, U/L | Males | 44.50 ± 13.6 | 55.65 ± 14.3* | 56.90 ± 14.8** | 52.05 ± 14.5 |
| Females | 35.40 ± 15.2 | 40.53 ± 9.9 | 44.27 ± 14.1 | 42.60 ± 9.9 | |
| K, mmol/L | Males | 5.18 ± 0.4 | 5.08 ± 0.5 | 5.34 ± 0.5 | 5.31 ± 0.5 |
| Females | 4.79 ± 0.5 | 5.03 ± 0.6 | 5.29 ± 0.6* | 4.92 ± 0.4 | |
| Na, mmol/L | Males | 148.20 ± 2.1 | 146.40 ± 3.0* | 146.75 ± 2.5 | 147.65 ± 2.1 |
| Females | 147.53 ± 3.3 | 147.47 ± 3.9 | 145.47 ± 2.9 | 146.47 ± 1.8 | |
| Cl, mmol/L | Males | 104.00 ± 2.0 | 101.75 ± 2.1** | 101.85 ± 2.2** | 103.55 ± 2.3 |
| Females | 105.07 ± 2.8 | 103.00 ± 2.3* | 102.60 ± 2.1* | 104.33 ± 1.7 | |
| HCO3, mmol/L | Males | 21.10 ± 2.8 | 20.15 ± 3.4 | 20.25 ± 2.4 | 22.00 ± 1.8 |
| Females | 19.87 ± 2.8 | 16.80 ± 3.5* | 18.53 ± 2.3 | 20.13 ± 2.0 | |
Abbreviations: A: G ratio, Albumin to globulin ratio; ALB, Albumin; ALP, Alkaline phosphatase; ALT, Alanine transaminase; AST, Aspartate aminotransferase; Ca, Calcium; CHOL, Cholesterol; Cl, Chlorine; CREA, Creatinine; CRP, C-reactive protein; GGT, Gamma-glutamyl transferase; GLOB, Globulin; GLU, Glucose; HCO3, Bicarbonate; K, Potassium; Na, Sodium; PHOS, Phosphorus; TBIL, Total bilirubin; TP, Total protein; TRIG, Triglyceride; UN, Urea nitrogen.
*
P < .05. **P < .01 relative to the 4-hour time point.