Synthesis of 2,3-dihydroquinazolin-4(1H)-ones using UiO-66-NH₂-MOF@COF as a catalyst^a.

Entry	R	Amine (ArNH2 or NH4OAC)	Product	Time (min)	Yieldb (%)	M.p. °C	Lit. M.p. oC
1	H	Ph	4a	20	91	213–215	214–216 (ref. 56)
2	4-Me	Ph	4b	14	85	211–213	213–214 (ref. 57)
3	4-OMe	Ph	4c	15	89	202–204	205–207 (ref. 33)
4	4-Cl	Ph	4d	16	94	220–223	222–224 (ref. 33)
5	3-NO2	Ph	4e	12	92	183–185	186–188 (ref. 57)
6	4-NO2	Ph	4f	10	98	192–194	195–197 (ref. 57)
7	4-Me	4-MeC6H4	4g	25	90	244–246	243–247 (ref. 58)
8	4-OMe	4-ClC6H4	4h	18	87	243–245	244–247 (ref. 59)
9	4-F	4-Me	4i	17	93	240–242	241–243 (ref. 59)
10	4-Cl	5-Cl, 2-OHC6H3	4j	10	89	233–236	235–237 (ref. 58)
11	2,6-Cl2	Ph	4k	14	93	231–232	234–236 (ref. 57)
12	4-Br	Ph	4l	16	96	218–220	221–223 (ref. 57)
13	4-SMe	4-BrC6H4	4m	25	94	246–248	—c
14	3-NO2	NH4OAC	6a	20	91	184–186	186–188 (ref. 33)
15	2-Cl	NH4OAC	6b	15	96	202–204	203–205 (ref. 56)
16	4-OH, 3-OMe	NH4OAC	6c	25	87	223–225	226–227 (ref. 33)
17	H	NH4OAC	6d	20	91	222–224	225–226 (ref. 57)
18	4-OMe	NH4OAC	6e	17	93	187–189	192–193 (ref. 57)
19	4-Me	NH4OAC	6f	19	89	230–232	233–234 (ref. 57)
20	4-SMe	NH4OAC	6g	20	87	235–237	—c

^aReaction conditions: UiO-66-NH₂-MOF@COF (0.007 g), isatoic anhydride, aldehyde, aryl amine or NH₄OAc (1 : 1 : 1 molar ratio) under free solvent conditions.

^bIsolated yield.

^cNew products.