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. Author manuscript; available in PMC: 2023 Dec 5.
Published in final edited form as: J Alzheimers Dis. 2023;95(3):915–929. doi: 10.3233/JAD-230548

Figure 2. Associations of polygenic risk scores with diagnostic status.

Figure 2.

Logistic regressions were used with diagnostic status (cognitively unimpaired vs dementia) as the outcome. Separate models used each PRS as predictor. Models either 1) included number of APOE-ε4 alleles as a separate variable, 2) tested only APOE-ε4 non-carriers, or 3) tested only APOE-ε4 carriers. All models adjusted for age, gender, and the first 3 genetic principal components. Plots show standardized regression coefficients (log-odds) and standard errors. Associations that survived FDR correction are bolded.