TABLE 2.
Ante mortem fragmentation of rest periods and composite expression of genes characteristic of reactive astrocytes: adjustment for neuropathology and clinical factors
| Model | Outcome | Covariates | Predictor | Estimate (per 1 SD greater kRA) | SE | P-value |
|---|---|---|---|---|---|---|
| A | Composite expression of activated astrocyte genes | Age + sex + education + post mortem interval + amyloid + neurofibrillary tangle density | Ante mortem level of rest fragmentation kRA | 0.08 | 0.025 | 1.45E-03 |
| B | Composite expression of activated astrocyte genes | A + all pathologiesa | Ante mortem level of rest fragmentation kRA | 0.09 | 0.03 | 7.38E-04 |
| C | Composite expression of activated astrocyte genes | A + all clinical covariatesb | Ante mortem level of rest fragmentation kRA | 0.08 | 0.03 | 1.65E-03 |
a
Amyloid level, tangle density, Lewy body pathology, macroscopic cerebral infarcts, microinfarcts, TDP-43 pathology, hippocampal sclerosis, cerebral amyloid angiopathy, cerebral atherosclerosis, and arteriolosclerosis.
b
Smoking, alcohol consumption, use of sleeping pills, body mass index, vascular disease, and vascular risk factors.
Abbreviations: SD, standard deviation; SE, standard error; TDP-43, TAR DNA-binding protein 43.