TABLE 3.
The characteristics of ISR due to infection in different time phases after transplantation.
| Characteristics | Patients with ISR due to infection (n = 103) | p-value | |||
|---|---|---|---|---|---|
| ≤1 month (group 1, n = 25) | 2–6 months (group 2, n = 20) | 7–12 months (group 3, n = 30) | >12 months (group 4, n = 28) | ||
| Infections leading to first ISR, n (%) | |||||
| Pulmonary infection | 10 (40.0) | 12 (60.0) | 16 (53.3) | 11 (39.3) | 0.410 |
| Urinary tract infection | 12 (48.0) | 5 (25.0) | 2 (6.7) a | 1 (3.6) a | <0.001 |
| BKPyV infection | 0 (0.0) | 2 (10.0) | 11 (36.7) a , b | 13 (46.4) a , b | <0.001 |
| Other infections | 3 (12.0) | 1 (5.0) | 1 (3.3) | 3 (10.7) | 0.590 |
| Patients with ISW, n (%) | 3 (12.0) | 5 (25.0) | 6 (20.0) | 8 (28.6) | 0.498 |
| Patients with repeated ISR, n (%) | 8 (32.0) | 6 (30.0) | 12 (40.0) | 6 (21.4) | 0.507 |
| Infections leading to repeated ISR, n (%) | |||||
| Pulmonary infection | 3 (12.0) | 1 (5.0) | 4 (13.3) | 1 (3.6) | 0.534 |
| Urinary infection | 1 (4%) | 1 (5.0) | 0 (0.0) | 0 (0.0) | 0.343 |
| BKPyV infection | 6 (24.0) | 4 (20.0) | 7 (23.3) | 4 (14.3) | 0.822 |
| Other infections | 0 (0.0) | 1 (5.0) | 1 (3.3) | 1 (3.6) | 0.881 |
| Duration of first ISR (days), mean ± SD | 35.12 ± 78.1 | 54.6 ± 141.6 | 221.9 ± 328.9 a | 278.9 ± 345.7 a , b | 0.002 |
| Pulmonary infection | 26.3 ± 30.9 | 30.3 ± 29.1 | 43.1 ± 70.7 | 26.27 ± 21.6 | 0.748 |
| Urinary tract infection | 15.6 ± 13.4 | 9.6 ± 7.0 | 6.5 ± 3.5 | 4 | 0.546 |
| BKPyV infection | — | 336.5 ± 439.1 | 496.7 ± 394.2 | 560.9 ± 326.8 | 0.702 |
| Other sites | 142.7 ± 218.7 | 7.0 | 491.0 | 74.7 ± 44.1 | 0.248 |
Abbreviations: ISR, immunosuppressants reduction; ISW, immunosuppressants withdrawal (completely stopping TAC and MMF); BKPyV, BK polyomavirus.
a
Significantly different from group 1.
b
Significantly different from group 2.