Table 1.
Baseline Characteristics of SCCS Participants by Gastric Cancer Status
| Control Cohort (n = 81,681) |
Gastric Cancer Cases (n = 203) * |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-Cardia (n = 142) | Cardia (n = 31) | |||||||||||
| N | % | Mean | STD | N | % | Mean | STD | N | % | Mean | STD | |
| Age at enrollment, years a | 52 | 8.8 | 58 | 9.6 | 59 | 8.0 | ||||||
| Sex b | ||||||||||||
| Female | 48,515 | 59.4 | 71 | 50.0 | 8 | 25.8 | ||||||
| Male | 33,166 | 40.6 | 71 | 50.0 | 23 | 74.2 | ||||||
| Race b | ||||||||||||
| White | 24,649 | 30.2 | 25 | 17.6 | 20 | 64.5 | ||||||
| Black/African American | 53,372 | 65.3 | 113 | 79.6 | 10 | 32.3 | ||||||
| Other (His, As, NA, Mix) | 3,233 | 4.0 | 1 | 0.7 | 1 | 3.2 | ||||||
| Unknown | 427 | 0.5 | 3 | 2.1 | 0 | 0.0 | ||||||
| Body mass index, [kg/m2] | 30.3 | 7.5 | 29.4 | 7.4 | 29.5 | 7.7 | ||||||
| Education c | ||||||||||||
| Less than high school/GED | 23,221 | 28.4 | 53 | 37.3 | 8 | 25.8 | ||||||
| High School | 26,700 | 32.7 | 50 | 35.2 | 11 | 35.5 | ||||||
| Some/Junior college | 20,656 | 25.3 | 19 | 13.4 | 5 | 16.1 | ||||||
| College degree | 6,596 | 8.1 | 10 | 7.0 | 4 | 12.9 | ||||||
| More than college | 4,086 | 5.0 | 6 | 4.2 | 3 | 9.7 | ||||||
| Unknown | 422 | 0.5 | 4 | 2.8 | 0 | 0 | ||||||
| Household income | ||||||||||||
| <$15,000 | 44,290 | 54.2 | 75 | 52.8 | 16 | 51.6 | ||||||
| $15,000 – <$25,000 | 16,956 | 20.8 | 36 | 25.4 | 6 | 19.4 | ||||||
| $25,000 – <$50,000 | 11,400 | 14.0 | 18 | 12.7 | 3 | 9.7 | ||||||
| $50,000 – <$100,000 | 5,891 | 7.2 | 6 | 4.2 | 4 | 12.9 | ||||||
| ≥$100,000 | 1,959 | 2.4 | 3 | 2.1 | 2 | 6.5 | ||||||
| Unknown | 1,185 | 1.5 | 4 | 2.8 | 0 | 0.0 | ||||||
| Insurance c | ||||||||||||
| No | 31,852 | 39.0 | 43 | 30.3 | 12 | 38.7 | ||||||
| Yes | 49,712 | 60.9 | 99 | 69.7 | 19 | 61.3 | ||||||
| Unknown | 117 | 0.1 | 0 | 0.0 | 0 | 0.0 | ||||||
| Geographic Deprivation Index Group (Quartile) | ||||||||||||
| Q1 | 8,695 | 10.7 | 7 | 4.9 | 7 | 22.6 | ||||||
| Q2 | 12,979 | 15.9 | 23 | 16.2 | 4 | 12.9 | ||||||
| Q3 | 17,036 | 20.9 | 25 | 17.6 | 5 | 16.1 | ||||||
| Q4 | 41,806 | 51.2 | 83 | 58.5 | 14 | 45.2 | ||||||
| Unknown | 1,165 | 1.4 | 4 | 2.8 | 1 | 3.2 | ||||||
| Family history of gastric cancer | ||||||||||||
| No/unknown | 79,083 | 96.8 | 136 | 95.8 | 31 | 100.0 | ||||||
| Yes | 2,598 | 3.2 | 6 | 4.2 | 0 | 0.0 | ||||||
| Diabetes c | ||||||||||||
| No | 64,238 | 78.6 | 97 | 68.3 | 24 | 77.4 | ||||||
| Yes | 17,406 | 21.3 | 45 | 31.7 | 7 | 22.6 | ||||||
| Unknown | 37 | 0.1 | 0 | 0.0 | 0 | 0.0 | ||||||
| Ulcer c | ||||||||||||
| No | 71,329 | 87.3 | 114 | 80.3 | 29 | 93.6 | ||||||
| Yes | 10,266 | 12.6 | 27 | 19.0 | 2 | 6.5 | ||||||
| Unknown | 86 | 0.1 | 1 | 0.7 | 0.0 | |||||||
| Reflux | ||||||||||||
| No | 58,875 | 72.1 | 104 | 73.2 | 22 | 71.0 | ||||||
| Yes | 22,760 | 27.9 | 38 | 26.8 | 9 | 29.0 | ||||||
| Unknown | 46 | 0.1 | 0 | 0.0 | 0 | 0.0 | ||||||
| Smoking Status b | ||||||||||||
| Never | 29,266 | 35.8 | 37 | 26.1 | 5 | 16.1 | ||||||
| Former | 18,684 | 22.9 | 48 | 33.8 | 13 | 41.9 | ||||||
| Current, <20 cigs/day | 21,208 | 26.0 | 37 | 26.1 | 4 | 12.9 | ||||||
| Current, ≥20 cigs/day | 11,802 | 14.5 | 17 | 12.0 | 9 | 29.0 | ||||||
| Unknown | 721 | 0.9 | 3 | 2.1 | 0 | 0.0 | ||||||
| Alcohol | ||||||||||||
| Never/Rarely | 24,138 | 29.6 | 41 | 28.9 | 6 | 19.4 | ||||||
| 1-3 times per month | 8,199 | 10.0 | 10 | 7.0 | 2 | 6.5 | ||||||
| 1-4 times per week | 25,564 | 31.3 | 47 | 33.1 | 9 | 29.0 | ||||||
| Daily/Nearly Daily | 23,111 | 28.3 | 43 | 30.3 | 14 | 45.2 | ||||||
| Unknown | 669 | 0.8 | 1 | 0.7 | 0 | 0.0 | ||||||
*
The 30 gastric cancers with unknown site were excluded from this table, and further analyses.
a
P < 0.05 for both NCGC and CGC compared to the control cohort, ANOVA F test.
b
P < 0.05 for both NCGC and CGC compared to the control cohort, Chi-Square test, two-sided.
c
P < 0.05 for NCGC compared to the control cohort, Chi-Square test, two-sided.