Table 4.
Associations between Use of Specific Supplements and Incident Gastric Cancer by Histologic Site among Participants in the SCCS
Non-Cardia Gastric Cancer a | Cardia Gastric Cancer b | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Events | Person-years* | HR a | 95% CI | P-value | Events | Person-years* | HR b | 95% CI | P-value | |
Any Supplement | ||||||||||
Rarely/never | 84 | 503,945 | REF | 15 | 507,543 | REF | ||||
Sometimes/always | 52 | 446,374 | 0.70 | 0.49-0.99 | 0.04 | 16 | 451,749 | 0.93 | 0.45-1.92 | 0.85 |
Multivitamin | ||||||||||
Rarely/never | 94 | 577,004 | REF | 16 | 581,089 | REF | ||||
Sometimes/always | 41 | 351,074 | 0.73 | 0.50-1.06 | 0.10 | 14 | 354,325 | 1.16 | 0.56-2.39 | 0.70 |
Vitamin C | ||||||||||
Rarely/never | 113 | 779,663 | REF | 25 | 785,206 | REF | ||||
Sometimes/always | 18 | 142,336 | 0.91 | 0.55-1.51 | 0.73 | 5 | 144,418 | 0.84 | 0.32-2.20 | 0.72 |
Vitamin E | ||||||||||
Rarely/never | 116 | 788,044 | REF | 25 | 793,658 | REF | ||||
Sometimes/always | 15 | 134,359 | 0.74 | 0.43-1.28 | 0.28 | 4 | 136,262 | 0.70 | 0.24-2.02 | 0.50 |
Calcium | ||||||||||
Rarely/never | 119 | 786,549 | REF | 26 | 792,091 | REF | ||||
Sometimes/always | 12 | 138,117 | 0.61 | 0.33-1.12 | 0.11 | 3 | 140,069 | 0.56 | 0.16-1.91 | 0.36 |
Garlic pills | ||||||||||
Rarely/never | 127 | 864,534 | REF | 28 | 870,995 | REF | ||||
Sometimes/always | 3 | 51,018 | 0.33 | 0.11-1.05 | 0.06 | 1 | 51,679 | 0.49 | 0.07-3.61 | 0.48 |
HR adjusted for enrollment age, race (black/white), sex, smoking status (ever/never), diagnosis of stomach or small intestine ulcer, diagnosis of diabetes
HR adjusted for enrollment age, race (black/white), and sex
Person-years is calculated based records with non-missing covariates that are used for adjustment respectively