Table 5.

Associations between Use of Specific Supplements and Incident Non-Cardia Gastric Cancer among Participants in the SCCS, stratified by HEI level

	Non-Cardia Gastric Cancer
	Healthy Eating Index < Median a					Healthy Eating Index ≥ Median a
	Events	Person-years*	HR b	95% CI	P-value	Events	Person-years*	HR b	95% CI	P-value
Any Supplement
Rarely/never	44	281,673	REF			40	193,078	REF
Sometimes/always	12	166,111	0.48	0.25-0.92	0.03	36	259,757	0.70	0.44-1.10	0.12
Multivitamin
Rarely/never	50	311,882	REF			44	232,891
Sometimes/always	6	129,337	0.30	0.13-0.71	0.01	31	206,976	0.84	0.53-1.34	0.48
Vitamin C
Rarely/never	53	395,763	REF			58	343,335
Sometimes/always	3	43,714	0.58	0.18-1.86	0.36	13	91,650	0.92	0.50-1.69	0.78
Vitamin E
Rarely/never	54	399,380	REF			59	347,591
Sometimes/always	2	40,075	0.38	0.09-1.56	0.18	12	87,899	0.83	0.44-1.55	0.55
Calcium Supplement
Rarely/never	54	400,958	REF			62	343,793
Sometimes/always	2	38,853	0.49	0.12-2.03	0.32	9	93,525	0.56	0.27-1.15	0.11
Garlic Pills
Rarely/never	55	424,926	REF			68	395,134
Sometimes/always	1	12,716	0.53	0.07-3.81	0.53	2	36,060	0.29	0.07-1.17	0.08

^aHEI Median is 57.53, and it was calculated based on 81,884 subjects with non-missing HEI value, i.e., the median of (81884-4508 = 77,376) participants HEI value

^bHR adjusted for enrollment age, race (black/white), sex, smoking status (ever/never), diagnosis of stomach or small intestine ulcer, diagnosis of diabetes

^*Person-years is calculated based records with non-missing covariates that are used for adjustment, respectively