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. Author manuscript; available in PMC: 2023 Dec 5.
Published in final edited form as: Br J Pharmacol. 2021 Apr 30;178(13):2709–2726. doi: 10.1111/bph.15463

FIGURE 8.

FIGURE 8

Compounds 10 and 5 enhanced spontaneous excitatory transmission in spinal lamina II neurons of adult male mice (n = 6–7 neurons per group; individual values are shown). (a) Recordings of sEPSCs in the absence and presence of compound 10. (b) Recordings of sEPSCs in the absence and presence of compound 5. (c and d) Mean ± SEM changes in the sEPSCs frequency (left) and amplitude (right) before and under the action of compound (c) 10 or (d) 5. The duration of drug superfusion is shown by a horizontal bar above the chart recording, and two consecutive traces of sEPSCs for a period indicated by a short bar below the chart recording are shown in an expanded time scale. VH = −70 mV. *P < 0.05, significantly different as indicated; Student’s t-test