Table 2:

Transcription factor enrichment of increased and decreased proteins within each tissue and time point from the ENCODE and CHEA consensus transcription factors in Enrichr. Listed TFs are significant (adjusted p<0.05). Bolded TFs are relevant to developmental processes based on GeneCard summaries.

Visceral Yolk Sac			Embryo
	Decreased	Increased	Decreased	Increased
2 hr	MYC, MAX, E2F6	IRF1	NELFE, BRCA1, ZMIZ1, CREB1, YY1, CHD1	NRF1, UBTF, TAF1, ATF2, CHD1, ELF1, YY1, SPI1, CTCF, RCOR1, CREB1, GABPA, BRCA1, TCF3, MAX, ZNF384
4 hr	-	-	E2F1, ZNF384, RFX5, E2F4, NRF1, TCF3, NANOG	MYC, TAF1, GABPA, SIN3A, E2F1, FLI1, MAX, ZNF384, SPI1, BRCA1, ELF1, PML, ZBTB7A, TCF3, KLF4, YY1
6 hr	TAF1, MAX, MYC, ZMIZ1, CREB1, FLI1, BRCA1, NRF1, ELF1, USF2, ZNF384, SIN3A, GABPA, ATF2, YY1, ZBTB33, USF1, NFYB, PBX3, CEBPD, CHD1, NFYA, SPI1, NELFE, HNF4A, TAF7	NFYB, NFYA, MAX, MYC, GABPA, CTCF, E2F1, SP2, BRCA1, NRF1, PBX3, IRF3, RFX5, SPI1, UBTF, CREB1, TAF1, E2F6, FLI1, ZBTB7A, ATF2	NR2C2, MYC, YY1, ZNF384, MAX, GABPA	-
8 hr	TAF1, MYC, YY1, UBTF, ATF2, PML, SIN3A, MAX, ZNF384, BRCA1, CREB1, KLF4, E2F1, TCF3, GABPA, NFIC, STAT3, USF2, PPARG, E2F4	BRCA1, ELF1, NFYB, CREB1, TAF1, NFYA, CHD1, SIX5, GABPA, YY1, EGR1	TAF1, E2F4, NRF1, E2F6, MYC, GABPA SIN3A, YY1, MAX, TAF7, ATF2, E2F1, CREB1, ELF1, BRCA1, CHD1, PML, ZBTB33, RUNX1, ZNF384	TAF1, YY1, NRF1, ATF2, MAX, SIN3A, PML, E2F6, ELF1, MYC, USF2, TAF7, E2F1, GABPA, RFX5, SPI1
10 hr	USF2, USF1, HNF4A, ELF1, SPI1, BRCA1	TAF1, CREB1, YY1, UBTF, MYC, BRCA1, SIN3A, MAX, NRF1, E2F4, NFYA, ELF1, TCF3, E2F1, ZMIZ1, EGR1, PML, E2F6, USF1, FOXP2, ATF2	YY1, KLF4, MYC, TAF1, MAX	ZNF384