Table 1.
Comparison of risk factors between babies with severe retinopathy of prematurity, nonsevere retinopathy of prematurity and no retinopathy of prematurity
| Group A1 (severe ROP), n (%) | Group A2 (nonsevere ROP), n (%) | Group B (no ROP), n (%) | P | |
|---|---|---|---|---|
| Gender† | ||||
| Male | 40 (64.5) | 61 (59.8) | 214 (52.2) | 0.104 |
| Female | 22 (35.5) | 41 (40.2) | 196 (47.8) | |
| Gestational age‡ (weeks) | 27.8±1.9 | 29.4±2 | 31.7±1.9 | 0.005* |
| Birth weight‡ (g) | 940.6±218.1 | 1185.5±366 | 1557.9±401.1 | 0.005* |
| Presence of SGA† | 12 (19.4) | 14 (13.7) | 78 (19) | 0.401 |
| Presence of IUGR† | 14 (22.6) | 17 (16.7) | 57 (13.9) | 0.193 |
| Apgar (≤6) at 1 min† | 33 (53.2) | 48 (47.1) | 104 (25.4) | 0.0005* |
| Apgar (≤6) at 5 min† | 6 (9.7) | 5 (4.9) | 19 (4.6) | 0.248 |
| RDS† | 61 (98.4) | 84 (82.4) | 289 (70.5) | 0.0005* |
| Apnoea of prematurity† | 52 (83.9) | 60 (58.8) | 113 (27.6) | 0.0005* |
| Need for surfactant† | 27 (43.5) | 33 (32.4) | 56 (13.7) | 0.0005* |
| BPD† | 30 (48.4) | 11 (10.8) | 12 (2.9) | 0.0005* |
| Acyanotic heart disease† | 34 (54.8) | 33 (32.4) | 50 (12.2) | 0.0005* |
| PDA† | 27 (43.5) | 27 (26.5) | 40 (9.8) | 0.0005* |
| Combined acyanotic heart disease† | 8 (12.9) | 13 (12.7) | 14 (3.4) | 0.0005* |
| IVH† | 15 (24.2) | 12 (11.8) | 29 (7.1) | 0.0005* |
| Ileus of prematurity† | 6 (9.7) | 8 (7.8) | 11 (2.7) | 0.007* |
| Anaemia† | 42 (67.7) | 30 (29.4) | 38 (9.3) | 0.0005* |
| Thrombocytopenia† | 13 (21) | 9 (8.8) | 17 (4.1) | 0.0005* |
| History of blood transfusion† | 39 (62.9) | 27 (26.5) | 32 (7.8) | 0.0005* |
| Sepsis† | 26 (41.9) | 16 (15.7) | 30 (7.3) | 0.0005* |
| History of any surgery undergone by the baby during their stay in NICU† | 14 (22.6) | 9 (8.8) | 15 (3.7) | 0.0005* |
| Oxygen support required† | 61 (98.4) | 87 (85.3) | 300 (73.2) | 0.0005* |
| Number of days of oxygen support required‡ | 30.3±25.6 | 11±16.4 | 4.2±7.4 | 0.0005* |
| Number of days on ventilator‡ | 7±9.4 | 2.3±6 | 0.5±2.6 | 0.0005* |
| PCA at which babies underwent surgery‡ | 35.2±9 | 37.1±2.7 | 37.1±5.3 | 0.703 |
*P<0.05 was considered significant, †Calculated as number, percentage, Chi-square test used, ‡Calculated as mean±SD, one-way ANOVA test used. SD: Standard deviation, ROP: Retinopathy of prematurity, SGA: Small for gestational age, IUGR: Intrauterine growth restriction, RDS: Respiratory distress syndrome, BPD: Bronchopulmonary dysplasia, PDA: Patent ductus arteriosus, IVH: Intraventricular hemorrhage, NICU: Neonatal intensive care unit, PCA: Postconceptional age