Table 3.
Sequential Multiple Regression Models of Quality of Life in the Total Sample and in Patients With Mild and Moderate-to-Severe Cognitive Impairment
| β | Significance, P Values | R 2 | |
|---|---|---|---|
| Model 1: total sample (n = 115) | |||
| Neuropsychiatric symptoms | −.377 | .001 c | .264 |
| Functional limitations (DAD) | −.118 | .446 | |
| Illness severity (CDR-SOB) | .051 | .707 | |
| Frailty | −.192 | .047 c | |
| Model 2: MMSE ≥ 21 (n = 71) | |||
| Neuropsychiatric symptoms a | −.505 | .0001 d | .362 |
| Functional limitations (DAD) | .030 | .845 | |
| Illness severity (CDR-SOB) b | −.070 | .595 | |
| Frailty | −.240 | .037 c | |
| Model 3: MMSE ≤ 20 (n = 44) | |||
| Neuropsychiatric symptoms | −.121 | .567 | .377 |
| Functional limitations (DAD) | −.798 | .017 c | |
| Illness severity (CDR-SOB) | .472 | .113 | |
| Frailty | −.212 | .250 | |
Abbreviations: MMSE, Mini-Mental State Examination; CESD, Center for the Epidemiological Studies–Depression; CDR, Clinical Dementia Rating; SOB, Sum of Boxes; NPI, Neuropsychiatric Inventory; DAD, Disability Assessment for Dementia scale.
a NPI.
b Washington University CDR scale SOB score.
c Statistically significant: P < .05.
d Statistically significant: P < .001.