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. 2023 Nov 29;43(48):8126–8139. doi: 10.1523/JNEUROSCI.0631-23.2023

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Copyright © 2023 Marin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — Ad libitum access to a complex running wheel does not enhance remyelination, nor does it enhance recovery of nodes of Ranvier at the peri-infarct following WMS. A, Representative images of regenerated myelin formed at peri-infarct and the same myelin sheaths isolated for quantification. B, C, Quantification of the number of myelin sheaths per FOV at the peri-infarct (B) and their average length (C). D, Representative images of a paranode colocalized to myelin sheaths in subcortical white matter. E, Representative images of paranodes colocalized to myelin sheaths at the peri-infarct. F, Quantification of the ratio of paranodes colocalized to regenerated myelin sheaths to the total area of GFP at the peri-infarct. G, Representative images of the nodes of Ranvier at the peri-infarct. H, Quantification of the number of nodes of Ranvier per FOV at the peri-infarct. *Location of stroke. Scale bars: A, D, E, 40 μm; G, 10 μm.