Figure 10.

miR-218 regulates synaptic related genes. a, Chord diagram clustering the top 20 GO:CC enriched terms for miR-218, miR-29a, miR-34b/c, and miR-204/211 reported in Extended Data Figure 10-1. b, Diagram represents the SynGO:BP enriched terms for the miR-218's targets. The list of annotated genes is reported in Extended Data Figure 10-2. c, Venn diagram that groups miR-218 target genes on the basis of their expression in epiSC-derived and MEF-derived DAn. And for their annotation as synaptic related in SynGO. d, Magnification of heatmap in Extended Data Figure 10-2 for the selected genes. e, qPCR analysis for the expression of selected miR-218's target genes in the ventral midbrain of P39 WT and cKO mice. Data were normalized to the average of the reference Hprt and related to the expression levels of Ctrl (=1), and represent the mean ± SEM of 2^−ΔΔCt values from at least 3 distinct animals. *p < 0.05 of at least one of one of KO samples with respect to the Ctrl (two way-ANOVA plus Dunn's post hoc).