Table 1.
Survival rate of the miR-218-1 and miR-218-2 KO mice
| Mating | Genotype | Embryonal |
Adult |
||||
|---|---|---|---|---|---|---|---|
| No. of embryos | Observed frequency | Expected frequency | No. of animals | Observed frequency | Expected frequency | ||
| miR-218-1+/− × miR-218-1+/− | miR-218-1+/+ | 9 | 0.24 | 0.25 | 7 | 0.15 | 0.25 |
| miR-218-1+/− | 23 | 0.60 | 0.5 | 28 | 0.57 | 0.5 | |
| miR-218-1–/– | 5 | 0.16 | 0.25 | 14 | 0.28 | 0.25 | |
| Total 37 | χ2 test, p = 0.217 | Total 49 | χ2 test, p = 0.223 | ||||
| miR-218-2+/− × miR-218-2+/− | miR-218-2+/+ | 18 | 0.210 | 0.25 | 49 | 0.35 | 0.25 |
| miR-218-2+/− | 39 | 0.440 | 0.5 | 92 | 0.65 | 0.5 | |
| miR-218-2–/– | 31 | 0.350 | 0.25 | 0 | 0 | 0.25 | |
| Total 88 | χ2 test, p = 0.083 | Total 141 | χ2 test, p < 0.0001 | ||||
| miR-218-1+/−-2+/− × miR-218-1+/−-2+/− | miR-218-1+/+-2+/+ | 1 | 0.030 | 0.0625 | 11 | 0.096 | 0.0625 |
| miR-218-1+/+-2+/− | 3 | 0.091 | 0.125 | 22 | 0.193 | 0.125 | |
| miR-218-1+/+-2–/– | 2 | 0.061 | 0.0625 | 1 | 0.009 | 0.0625 | |
| miR-218-1+/+-2–/– | 5 | 0.152 | 0.125 | 20 | 0.175 | 0.125 | |
| miR-218-1+/−-2+/− | 10 | 0.303 | 0.25 | 37 | 0.325 | 0.25 | |
| miR-218-1+/−-2–/– | 8 | 0.242 | 0.125 | 1 | 0.009 | 0.125 | |
| miR-218-1–/–-2+/+ | 1 | 0.030 | 0.0625 | 10 | 0.088 | 0.0625 | |
| miR-218-1–/–-2+/− | 2 | 0.061 | 0.125 | 13 | 0.114 | 0.125 | |
| miR-218-1–/–-2–/– | 1 | 0.030 | 0.0625 | 0 | 0.0 | 0.0625 | |
| Total 33 | χ2 test, p = 0.511 | Total 115 | χ2 test, p < 0.0011 | ||||
The number of observed animals for each genotype at both E14.5 (embryonal) and P0 (adult) stages obtained from different mating. χ2-test was used to compare observed and expected frequencies.