Table 1. The PerSPEcTiF question formulation framework.

Per	S	P	E	(C)	Ti	F
Perspective	Setting	Phenomenon of interest/ Problem	Environment	Comparison (optional)	Time/ Timing	Findings
Parents, other family members, parent representatives, healthcare providers, policymakers, researchers	Any setting	The outcomes of treatments for neonatal sepsis are important to parents, other family members, parent representatives, healthcare providers, policymakers, and researchers that should be included in a ’long list’ of outcomes contributing to the COS	High, middle and low-income countries	-	Anytime following diagnosis of sepsis	All outcomes regarding the phenomenon of interest