Table 2. Median (IQR) plasma concentrations in original units according to control or intervention group at each time point.
| Preconception baseline | Preconception 1 month post-supplementation | Early pregnancy (7–11 weeks gestation) |
Late pregnancy (28 weeks gestation) |
6 months postdelivery | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 735–854) |
Intervention (n = 746–867) |
Controls (n = 692–707) |
Intervention (n = 724–747) |
Controls (n = 303–305) |
Intervention (n = 322–329) |
Controls (n = 261–288) |
Intervention (n = 270–293) |
Controls (n = 217–251) |
Intervention (n = 231–261) |
|
| Folate (nmol/L) |
22.5 (12.7, 41.3) |
20.5 (12.1, 41.3) |
41.9 (29.3, 55.0) |
40.3 (29.0, 52.8) |
49.8 (40.5, 60.0) |
52.2 (43.2, 63.0) |
41.5 (30.6, 51.6) |
44.1 (34.3, 54.5) |
19.2 (11.9, 32.7) |
18.9 (12.3, 32.2) |
| Homocysteine (μmol/L) |
7.0 (6.1, 8.4) |
7.1 (6.1, 8.5) |
6.9 (6.0, 8.0) |
6.4 (5.6, 7.4) |
5.5 (4.8, 6.4) |
4.9 (4.2, 5.6) |
4.6 (3.9, 5.2) |
3.9 (3.5, 4.6) |
7.4 (6.4, 9.0) |
7.2 (6.1, 8.5) |
| Riboflavin (nmol/L) |
12.7 (7.7, 21.7) |
12.0 (7.6, 21.2) |
12.7 (8.3, 22.3) |
24.7 (16.7, 36.8) |
10.7 (6.8, 18.0) |
20.0 (13.0, 30.3) |
10.3 (6.6, 15.1) |
16.9 (12.2, 23.3) |
12.9 (8.8, 21.1) |
12.7 (8.4, 22.6) |
| FMN (nmol/L) |
14.4 (11.5, 18.7) |
14.6 (11.9, 18.7) |
15.6 (12.4, 20.1) |
18.4 (15.0, 23.4) |
14.5 (11.4, 18.2) |
17.2 (14.3, 21.6) |
10.1 (8.4, 12.0) |
11.5 (9.8, 13.4) |
14.2 (11.8, 17.0) |
14.4 (11.2, 18.7) |
| Pyridoxal 5-phosphate (nmol/L) |
55.8 (40.3, 88.4) |
57.1 (41.1, 84.3) |
56.9 (43.0, 80.1) |
140.0 (102.0, 184.0) |
47.6 (34.3, 64.1) |
106.0 (76.0, 139.0) |
19.1 (14.7, 28.1) |
41.9 (30.3, 56.4) |
56.3 (40.0, 88.2) |
56.1 (40.5, 86.6) |
| HK ratio (no units) |
0.35 (0.29, 0.43) |
0.36 (0.29, 0.42) |
0.35 (0.29, 0.42) |
0.29 (0.24, 0.35) |
0.35 (0.28, 0.43) |
0.29 (0.24, 0.33) |
0.51 (0.41, 0.60) |
0.44 (0.37, 0.54) |
0.40 (0.32, 0.49) |
0.39 (0.32, 0.47) |
| Cobalamin (pmol/L) |
355.2 (283.1, 434.1) |
350.9 (278.8, 437.7) |
358.9 (284.0, 449.3) |
438.2 (353.3, 552.1) |
307.4 (240.2, 384.0) |
411.1 (332.0, 509.3) |
214.6 (177.3, 270.0) |
298.7 (247.9, 379.5) |
340.4 (264.5, 437.8) |
385.6 (312.3, 465.7) |
| MMA (μmol/L) |
0.13 (0.11, 0.17) |
0.13 (0.11, 0.17) |
0.15 (0.12, 0.19) |
0.15 (0.12, 0.19) |
0.12 (0.10, 0.15) |
0.11 (0.10, 0.14) |
0.14 (0.11, 0.20) |
0.12 (0.10, 0.15) |
0.15 (0.12, 0.20) |
0.14 (0.12, 0.17) |
| Vitamin D3 (nmol/L) |
51.0 (36.0, 65.3) |
50.1 (36.1, 65.8) |
51.7 (37.0, 65.5) |
61.1 (51.1, 73.3) |
53.3 (41.8, 69.5) |
69.6 (57.3, 81.2) |
62.9 (41.0, 87.5) |
92.8 (73.0, 106.9) |
62.5 (45.3, 77.6) |
64.6 (48.5, 77.6) |
FMN, flavin mononucleotide; HK ratio, 3′-hydroxykynurenine ratio; IQR, interquartile range; MMA, methylmalonic acid.