Table 4. Linear regressions of globally standardized analytes against intervention/control group, adjusted for site, ethnicity, and parity.
| Analyte | Preconception baseline | Preconception 1 month post-supplementation | Early pregnancy (7–11 weeks gestation) |
Late pregnancy (28 weeks gestation) |
6 months postdelivery | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | beta | p-value | 95% CI | n | beta | p-value | 95% CI | n | beta | p-value | 95% CI | n | beta | p-value | 95% CI | n | beta | p-value | 95% CI | |
| Folate | 1,642 | −0.048 | 0.357 | (−0.15, 0.05) | 1,451 | −0.033 | 0.381 | (−0.11, 0.04) | 633 | 0.059 | 0.243 | (−0.04, 0.16) | 567 | 0.123 | 0.029 | (0.01, 0.23) | 491 | −0.045 | 0.594 | (−0.21, 0.12) |
| Homocysteine | 1,721 | 0.033 | 0.419 | (−0.05, 0.11) | 1,454 | −0.232 | <0.0001 | (−0.30, −0.16) | 634 | −0.406 | <0.0001 | (−0.51, -0.30) | 581 | −0.401 | <0.0001 | (−0.52, −0.29) | 512 | −0.101 | 0.188 | (−0.25, 0.05) |
| Riboflavin | 1,721 | −0.063 | 0.181 | (−0.16, 0.03) | 1,454 | 0.775 | <0.0001 | (0.68, 0.87) | 634 | 0.783 | <0.0001 | (0.64, 0.93) | 581 | 0.656 | <0.0001 | (0.52, 0.79) | 512 | −0.012 | 0.877 | (−0.17, 0.14) |
| FMN | 1,721 | 0.055 | 0.232 | (−0.04, 0.15) | 1,454 | 0.368 | <0.0001 | (0.27, 0.47) | 634 | 0.485 | <0.0001 | (0.34, 0.63) | 581 | 0.336 | <0.0001 | (0.22, 0.45) | 512 | 0.065 | 0.399 | (−0.09, 0.22) |
| Pyridoxal 5-phosphate | 1,721 | −0.018 | 0.667 | (−0.10, 0.06) | 1,454 | 1.072 | <0.0001 | (1.00, 1.14) | 634 | 0.974 | <0.0001 | (0.86, 1.09) | 581 | 0.863 | <0.0001 | (0.73, 0.99) | 512 | 0.036 | 0.649 | (−0.12, 0.19) |
| HK ratio | 1,481 | −0.018 | 0.694 | (−0.11, 0.07) | 1,416 | −0.52 | <0.0001 | (−0.61, −0.43) | 625 | −0.648 | <0.0001 | (−0.77, −0.53) | 531 | −0.339 | <0.0001 | (−0.49, −0.19) | 448 | −0.183 | 0.073 | (−0.38, 0.02) |
| Cobalamin | 1,717 | −0.035 | 0.393 | (−0.12, 0.05) | 1,450 | 0.549 | <0.0001 | (0.46, 0.63) | 631 | 0.776 | <0.0001 | (0.65, 0.91) | 581 | 0.809 | <0.0001 | (0.67, 0.95) | 511 | 0.303 | <0.0001 | (0.16, 0.45) |
| MMA | 1,721 | 0.086 | 0.066 | (−0.01, 0.18) | 1,454 | −0.04 | 0.4 | (−0.13, 0.05) | 634 | −0.228 | 0.002 | (−0.37, −0.09) | 581 | −0.509 | <0.0001 | (−0.68, −0.34) | 512 | −0.185 | 0.016 | (−0.34, −0.03) |
| Vitamin D3 | 1,721 | −0.028 | 0.49 | (−0.11, 0.05) | 1,454 | 0.496 | <0.0001 | (0.42, 0.57) | 634 | 0.601 | <0.0001 | (0.49, 0.71) | 581 | 0.877 | <0.0001 | (0.72, 1.04) | 512 | 0.126 | 0.087 | (−0.02, 0.27) |
Positive beta values represent an xx higher SD in intervention group compared to control group, adjusting for site, ethnicity, and parity.
CI, confidence interval; FMN, flavin mononucleotide; HK ratio, 3′-hydroxykynurenine ratio; MMA, methylmalonic acid.