Table 4:
Examples of CAR-T cells clinical trials in T-cell Lymphomas
| Target* | Identifier | Phase of study | Type of CAR-T cells | Institution/Sponsor (Country) | Status |
|---|---|---|---|---|---|
| CD30 | NCT04952584 | I | Allogeneic CD30.CAR-EBVST cells | Baylor College of Medicine (United States) | Recruiting |
| NCT04083495 | II | Autologous CD30.CART cells | University of North Carolina (United States) | Recruiting | |
| NCT02917083 | I | Autologous CD30.CART cells | Baylor College of Medicine (United States) | Recruiting | |
| CD30 & CCR4 | NCT03602157 | I | Autologous CD30.CART cells +CCR4 | University of North Carolina (United States) | Recruiting |
| CD5 | NCT03081910 | I | Autologous CD5.CART cells | Baylor College of Medicine (United States) | Recruiting |
| NCT04594135 | I | CD5.CART cells | iCell Gene Therapeutics/Peking University People’s Hospital (China) | Recruiting | |
| CD7 | NCT03690011 | I | Autologous CD7.CART cells | Baylor College of Medicine (United States) | Recruiting |
| NCT05059912 | II | CD7.CART cells | The First Affiliated Hospital of Soochow University (China) | Recruiting | |
| NCT04823091 | I | Donor-derived CD7.CART cells | Wuhan Union Hospital (China) | Recruiting | |
| NCT05290155 | I | CD7.CART cells | Shanghai General Hospital (China) | Recruiting | |
| NCT05377827 | I | Allogeneic CD7.CART cells | Washington University School of Medicine (USA) | Not yet recruiting | |
| CD37 | NCT04136275 | I | Autologous CD37.CART cells | Massachusetts General Hospital (United States) | Recruiting |
| CD4 | NCT04162340 | I | Autologous CD4.CART cells | iCell Gene Therapeutics (China) | Recruiting |
| NCT04712864 | I | Autologous CD4.CART cells | Legend Biotech USA Inc (Multi-center) (United States) | Active, not recruiting | |
| CD147 | NCT05013372 | Early phase I | CD147.CART cells | Peking University People’s Hospital (China) | Not yet recruiting |
This table includes examples of studies investigating each target and not inclusive of all the ongoing studies listed on clinicaltrials.gov.