TABLE 3.
HBV-human junctions in HBV-infected HepG2-hNTCP-C4 cells and primary human hepatocytes determined by RAISING-sequencing
| Sample | No. total reads | HBV junction position | HBV genome | Human chromosome | Human junction position | Human gene |
|---|---|---|---|---|---|---|
| HepG2-hNTCP-C4 cells | 13 | 3166 | P, S | Chr12 | 120995394 | HNF1A |
| 11 | 3165 | P, S | Chr11 | 5946294 | OR56A3 | |
| 11 | 3180 | P, S | Chr12 | 120995632 | HNF1A | |
| 10 | 3166 | P, S | Chr12 | 120995816 | HNF1A | |
| 10 | 3180 | P, S | Chr12 | 120994967 | HNF1A | |
| 9 | 3168 | P, S | Chr12 | 120995765 | HNF1A | |
| 9 | 3180 | P, S | Chr7 | 7705852 | RPA3 | |
| 8 | 503 | P, S | Chr1 | 630538 | AL669831.3 | |
| 8 | 1242 | P | Chr6 | 12017287 | HIVEP1 | |
| 7 | 496 | P, S | Chr15 | 50125750 | ATP8B4 | |
| 7 | 1760 | X | Chr2 | 16922581 | (intergenic) | |
| 5 | 341 | P, S | Chr1 | 629360 | AL669831.3 | |
| 5 | 505 | P, S | Chr7 | 158071793 | PTPRN2 | |
| 5 | 1718 | X | Chr4 | 177918044 | LINC01098 | |
| 5 | 3180 | P, S | Chr5 | 134925420 | PCBD2 | |
| 5 | 3180 | P, S | ChrX | 50742917 | SHROOM4 | |
| Primary human hepatocytes | 61 | 1496 | P, X | Chr2 | 27496085 | (intergenic) |
| 15 | 1829 | C, X | Chr14 | 103430901 | MARK3 | |
| 11 | 1812 | X | Chr2 | 234648039 | (intergenic) | |
| 5 | 985 | P | Chr8 | 21705351 | GFRA2 |
Abbreviation: RAISING, Rapid Amplification of Integration Site without Interference by Genomic DNA contamination.