TABLE 4.

HBV-human junctions in HCC clinical samples determined by RAISING-sequencing

Patient ID	No. total reads	HBV junction position	HBV genome	Human chromosome	Human junction position	Human gene	(Figure 3)
HCC-6	13	1800	X	Chr15	20503423	HERC2P3	→ #1
(nontumor tissue)	5	1804	X	Chr7	1081173	C7orf50	→ #2
HCC-33	1009	1753	X	Chr18	67700005	AC114689.3	→ #1
(nontumor tissue)	77	1713	X	Chr2	200147042	(intergenic)
	40	1779	X	Chr3	139268965	MRPS22
	38	1634	X	Chr4	185836717	SORBS2
	28	1733	X	Chr2	226775817	IRS1
	22	1819	C, X	Chr14	71388644	SIPA1L1
	20	1654	X	Chr4	103537128	(intergenic)
	16	1753	X	Chr4	73897495	(intergenic)
	16	1828	C, X	Chr9	95148096	FANCC
	10	1820	C, X	Chr1	173944363	RC3H1
HCC-46	5965	1676	X	ChrX	27176279	AC107419.1	→ #1
(nontumor tissue)	1051	1646	X	Chr12	77598319	NAV3	→ #2
	790	1785	X	Chr4	102824385	UBE2D3	→ #3
	587	1751	X	Chr1	198862191	MIR181A1HG
	218	1818	C, X	Chr10	124502003	LHPP
	181	1829	C, X	Chr2	215420541	FN1
	84	1821	C, X	Chr1	235499700	B3GALNT2
	78	1928	C	Chr2	177509515	AGPS
	46	1829	C, X	Chr11	11206373	(intergenic)
	22	809	P, S	Chr8	88734382	AC090578.1
	22	1827	C, X	Chr2	195217190	(intergenic)
	18	1680	X	Chr2	235683893	AGAP1
	10	1775	X	Chr18	64561691	(intergenic)
	9	1826	C, X	Chr8	135688215	(intergenic)
	8	1687	X	Chr12	34822229	(intergenic)
	8	1824	C, X	Chr11	46364499	DGKZ

Abbreviation: RAISING, Rapid Amplification of Integration Site without Interference by Genomic DNA contamination.