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. 2023 Nov 9;9(1-4):154–171. doi: 10.1159/000535131

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© 2023 The Author(s). Published by S. Karger AG, Basel

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Fig. 1. — Genetic evidence that supports the link of lipids to AD and NPDs. a Disease gene set enrichment analysis by using DisGeNET in Enrichr (maayanlab.cloud/Enrichr/). Lipid- and lipid protein-related genes are from Reactome (reactome.org/PathwayBrowser/#/R-HSA-556833). Shown are the adjusted enrichment p values (in –log10 scale). b PheWAS-polygenic burden associations with human phenome in the UK Biobank (mrcieu.mrsoftware.org/PRS_atlas/). PRS of AD is calculated using a GWAS dataset with 74,046 individuals [21], and PRS of LDL is calculated using a GWAS dataset with 173,082 individuals [35]. PRS, polygenic risk score.