Table 2.
Demographic and biochemical characteristics of MAFLD with renal insufficiency in overweight/obese adults in 2021
| Characteristics | Before PSM | After PSM with gender and age | ||||
|---|---|---|---|---|---|---|
| renal insufficiency (n = 4,715) | normal renal function (n = 9,209) | p value | renal insufficiency (n = 3,924) | normal renal function (n = 3,924) | p value | |
| eGFR, mL/min/1.73 m2 | 79.9 (72.2, 85.4) | 101.0 (95.5, 107.4) | <0.001 | 80.7 (73.5, 85.8) | 101.0 (95.5, 107.4) | <0.001 |
| Scr, μmol/L | 90.0 (81.4, 97.1) | 72.0 (63.0, 79.6) | <0.001 | 91.5 (84.0, 98.1) | 72.0 (63.0, 79.6) | <0.001 |
| Gender (male), n (%) | 3,232 (68.5) | 7,704 (83.7) | <0.001 | 2,354 (60.0) | 2,354 (60.0) | – |
| Age, years | 47 (36, 57) | 45 (35, 54) | <0.001 | 44 (35, 56) | 45 (35, 54) | 0.673 |
| BMI, kg/m2 | 31.3 (29.4, 34.2) | 25.8 (24.7, 26.9) | <0.001 | 31.4 (29.4, 34.3) | 25.8 (24.7, 26.9) | <0.001 |
| Metabolic abnormalities | ||||||
| Elevated SBP, n (%) | 2,474 (52.5) | 4,195 (45.5) | <0.001 | 1,980 (50.5) | 1,774 (45.2) | <0.001 |
| Elevated DBP, n (%) | 2,245 (47.6) | 4,132 (44.9) | 0.002 | 1,864 (47.5) | 1,747 (44.5) | <0.001 |
| Elevated FBG, n (%) | 1,830 (38.8) | 3,279 (35.6) | <0.001 | 1,431 (36.5) | 1,712 (43.6) | <0.001 |
| Elevated TG, n (%) | 2,938 (62.3) | 5,381 (58.4) | <0.001 | 2,433 (62.0) | 2,216 (56.5) | <0.001 |
| Elevated TC, n (%) | 1,263 (26.8) | 2,223 (24.1) | 0.001 | 1,022 (26.0) | 977 (24.8) | <0.001 |
| Reduced HDL-C, n (%) | 2,534 (53.7) | 3,488 (37.9) | <0.001 | 2,008 (51.2) | 1,646 (41.9) | <0.001 |
| Elevated LDL-C, n (%) | 1,778 (37.7) | 3,264 (35.4) | 0.008 | 1,465 (37.3) | 1,428 (36.4) | <0.001 |
| Elevated UA, n (%) | 2,459 (52.1) | 3,018 (32.7) | <0.001 | 2,072 (52.8) | 1,033 (26.3) | <0.001 |
| ALT, IU/L | 23 (18, 30) | 24 (19, 35) | <0.001 | 23 (18, 30) | 24 (19, 35) | <0.001 |
| Elevated ALT, n (%) | 492 (10.3) | 1,651 (17.9) | <0.001 | 433 (11.0) | 644 (16.4) | <0.001 |
| FIB-4 | 1.13 (0.80, 1.58) | 0.84 (0.59, 1.20) | <0.001 | 1.06 (0.77, 1.50) | 0.84 (0.59, 1.20) | <0.001 |
| Fibrosis (FIB-4 ≥1.3), n (%) | 1,836 (38.9) | 1,850 (20.1) | <0.001 | 1,278 (32.6) | 817 (20.8) | <0.001 |
| FIB-4 <1.3, n (%) | 2,879 (61.1) | 7,359 (79.9) | <0.001 | 2,541 (64.8) | 3,097 (78.9) | <0.001 |
| 1.3≤ FIB-4 <2.67, n (%) | 1,623 (34.4) | 1,715 (18.6) | 1,236 (31.5) | 765 (19.5) | ||
| FIB-4 ≥2.67 (%), n (%) | 213 (4.5) | 135 (1.5) | 147 (3.7) | 62 (1.6) | ||
Elevated SBP: ≥130 mm Hg. Elevated DBP: ≥ 85 mm Hg. Elevated FBG: ≥5.6 mmol/L. Elevated TG: ≥1.7 mmol/L. Elevated TC: ≥5.2 mmol/L. Reduced HDL-C: <1.0 mmol/L for men and <1.3 mmol/L for women. Elevated LDL-C: ≥3.1 mmol/L. Elevated UA: ≥416 μmol/L for men and ≥357 μmol/L for women. Elevated ALT: >40 IU/L.