Table 2.
Endpoint events in the total study population according to body mass index class (No. [%])
| Normal weight (n = 678) | Overweight (n = 712) | Obese (n = 391) | |
|---|---|---|---|
| Event | Number of events (%) | ||
| Disease-free survival event a | 231 | 287 | 188 |
| Recurrence of the primary tumor | 112 (48) | 133 (46) | 97 (52) |
| Local recurrence | 20 (9) | 16 (6) | 13 (7) |
| Regional recurrence | 25 (11) | 24 (8) | 16 (9) |
| Distant recurrenceb | 83 (36) | 114 (40) | 83 (44) |
| Visceral | 44 (19) | 70 (24) | 43 (23) |
| Bone | 53 (23) | 66 (23) | 56 (30) |
| Soft tissue | 10 (4) | 21 (7) | 15 (8) |
| Other | 3 (1) | 1 (<1) | 5 (3) |
| Second, (non-)invasive breast cancer | 20 (9) | 30 (10) | 21 (11) |
| Second, non-breast cancer | 73 (32) | 72 (25) | 40 (21) |
| Death without prior breast cancer event | 29 (13) | 53 (18) | 36 (19) |
| Death from any cause | 153 | 204 | 127 |
| Breast cancer related | 79 (52) | 103 (51) | 65 (51) |
| Not breast cancer related | 62 (41) | 74 (36) | 49 (39) |
| Second primary malignancy | 35 (23) | 40 (20) | 18 (14) |
| Cardiovascular disease | 9 (6) | 13 (6) | 15 (12) |
| Other | 18 (12) | 21 (10) | 16 (13) |
| Unknown | 12 (8) | 27 (13) | 13 (10) |
a
Patients may have had multiple disease-free survival events at the same moment.
b
In some patients multiple locations of recurrence were reported.