Table 3.
Online resources that provide access to Drosophila phenotype information.
| Online resource [dataset(s)] | Phenotype information source | URL |
|---|---|---|
| Drosophila in vivo mutant phenotypes | ||
| Alliance | FlyBase curation (mutant allele phenotypes) | https://www.alliancegenome.org/ |
| FlyBase | FlyBase curation | https://flybase.org/ |
| Monarch | FlyBase curation | https://monarchinitiative.org/ |
| Drosophila in vivo RNAi phenotypes | ||
| FlyBase | FlyBase curation (includes GAL4 driver info) | https://flybase.org/ |
| FlyMine (at “Disease”) | FlyBase curation | https://www.flymine.org |
| G2F | “Disruption phenotype” from UniProt | https://www.gene2function.org |
| MARRVEL | FlyBase curation | https://marrvel.org/ |
| Monarch | FlyBase curation | https://monarchinitiative.org/ |
| RSVP Plus | FlyBase curation (RNAi phenotypes), TRiP-curated screen datasets, user submissions (includes GAL4 driver) | https://www.flyrnai.org/cgi-bin/RSVP_search.pl |
| Cell-based RNAi screen phenotypes | ||
| DRSC Gene Lookup | Genome-wide cell RNAi screen data (DRSC) | https://www.flyrnai.org/cgi-bin/DRSC_gene_lookup.pl |
| G2F | Cell RNAi screen data (DKFZ, DRSC, and other sources from GenomeRNAi) | https://www.gene2function.org |
| GenomeRNAi | Cell RNAi screen data (DRSC, DKFZ, and other sources) | http://www.genomernai.org/ |
| NCBI PubChem BioAssaya | Cell RNAi screen data (DRSC) | https://pubchem.ncbi.nlm.nih.gov/ |
| UP-TORR | Genome-wide cell RNAi data (DRSC) | https://www.flyrnai.org/up-torr |
| Cell-based CRISPR knockout screen phenotypes | ||
| G2F | Cell CRISPR screen data (DKFZ, DRSC, and other sources from GenomeCRISPR) | https://www.gene2function.org |
| GenomeCRISPR | Cell CRISPR screen data | http://genomecrispr.dkfz.de/ |
| BioGRID | CRISPR cell screen data | https://thebiogrid.org/ |
| Additionally displays phenotypes associated with genes from other species | ||
| G2F | OMIM and InterMine APIs | https://www.gene2function.org |
| MARRVEL | OMIM and model organism databases (MODs) | https://marrvel.org/ |
| Monarch | OMIM and MODs | https://monarchinitiative.org/ |
a A search for “DRSC” at the PubChem “Explore Chemistry” main page retrieves the DRSC as a data source and displays a list of 48 “BioAssays” (screens) associated with ∼39,000 DRSC “Substances” (double-stranded RNA reagents).