Table 3.

FDA Approved Weight Loss Medications and Their Efficacies

Drug	Year Approved	Dosage	Dosage form	Placebo-subtracted weight loss (%)
Semaglutide	2021	2.4 mg once weekly	Injection	12.4
Phentermine-Topiramate	2012	15/92 mg once daily	Oral	8.6
Liraglutide	2014	3 mg daily	Injection	5.4
Bupropion-naltrexone	2014	360/32 mg once daily	Oral	4.8
Phentermine	1959	30 mg once daily	Oral	4.4
Orlistat	1999	120 mg three times a day	Oral	3.8

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