Table 2.

Tumor microbiome predicted to upregulate pathways involved in epigenetic processes

Direction (tumours)	Pathway #	Fold Change	BH p-value*
Up	Glycine Betaine degradation M1	46.4	0.002
	Nylon-6 oligomer degradation M2	2.1	0.001
	Bifidobacterium shunt A3	1.9	< 0.001
	Ketogluconate metabolism 4	1.8	< 0.001
	Pyruvate fermentation to aceton A5	1.7	< 0.001
	Acetyl-coA fermatiation to butanoate II A6	1.6	0.003
	Photorespiration 7	1.5	0.003
Down	S-adenosyl-L-methionine cycle I M−6	0.7	0.002
	2-methylcitrate cycle I A−5	0.68	0.002
	L-Glutamate and L-glutamine biosynthesis −4	0.65	< 0.001
	NAD biosynthesis II−3	0.63	0.002
	Pyridoxal 5'-phospahe biosynthesis I M−2	0.6	0.001
	GDP-D-glycero-alpha-D-manno-heptose biosynthesis −1	0.1	0.002

^*All pathways differentially predicted to be involved in the metabolism of the tumour microbiome ($\left|\mathrm{FC}\right|$>1.3, Benjamini–Hochberg corrected p-value < 0.05). # Pathways associated with epigenetic modifiers are labelled as: methylation (M) or acetyl group donation (A)