Table 4.
Ambulatory and office blood pressure and antihypertensive drug burden over time
| Ambulatory blood pressure | Baseline | 3 months | 6 months | 1 year | 2 years | 3 years | Annual change (95% CI) | p value |
|---|---|---|---|---|---|---|---|---|
| (N = 20) | (N = 14) | (N = 17) | (N = 17) | (N = 17) | (N = 17) | |||
| Mean 24-h SBP (mmHg), mean ± SD | 129.5 ± 15.5 | 120.4 ± 9.8 | 120.5 ± 8.9 | 123.6 ± 10.9 | 121.2 ± 11.0 | 120.3 ± 12.7 | − 2.2 (− 3.9, − 0.6) mmHg | 0.01 |
| Mean 24-h DBP (mmHg), mean ± SD | 77.3 ± 9.3 | 73.2 ± 8.0 | 71.5 ± 6.2 | 74.3 ± 9.4 | 71.7 ± 6.5 | 69.9 ± 7.6 | − 1.9 (− 2.9, − 0.9) mmHg | < 0.001 |
| Daytime SBP (mmHg), mean ± SD | 132.3 ± 15.8 | 124.0 ± 10.3 | 124.3 ± 8.4 | 126.6 ± 11.9 | 124.2 ± 11.2 | 122.8 ± 12.4 | − 2.5 (− 4.2, − 0.8) mmHg | 0.004 |
| Daytime DBP (mmHg), mean ± SD | 79.5 ± 9.7 | 76.1 ± 8.6 | 74.5 ± 5.5 | 76.6 ± 10.0 | 74.5 ± 6.5 | 72.2 ± 8.3 | − 1.9 (− 3.0, − 0.9) mmHg | < 0.001 |
| Nighttime SBP (mmHg), mean ± SD | 120.7 ± 17.4 | 106.4 ± 12.1 | 110.4 ± 12.8 | 116.2 ± 11.8 | 113.4 ± 12.9 | 114.6 ± 16.7 | − 0.6 (− 2.7, 1.5) mmHg | 0.56 |
| Nighttime DBP (mmHg), mean ± SD | 70.1 ± 10.4 | 61.9 ± 6.0 | 63.9 ± 7.7 | 67.7 ± 10.2 | 64.9 ± 7.5 | 64.8 ± 7.8 | − 0.8 (− 2.0, 0.4) mmHg | 0.21 |
| Office blood pressure | Baseline | 3 months | 6 months | 1 year | 2 years | 3 years | Annual change (95% CI) | p value |
|---|---|---|---|---|---|---|---|---|
| (N = 20) | (N = 20) | (N = 19) | (N = 20) | (N = 18) | (N = 13) | |||
| Office SBP (mmHg), mean ± SD | 153.8 ± 15.2 | 133.7 ± 15.6 | 146.5 ± 15.1 | 132.8 ± 17.0 | 132.6 ± 15.7 | 136.3 ± 11.4 | − 4.3 (− 6.8, − 1.8) mmHg | 0.001 |
| Office DBP (mmHg), mean ± SD | 87.5 ± 10.4 | 81.1 ± 8.3 | 80.4 ± 10.5 | 80.5 ± 9.4 | 83.1 ± 10.0 | 80.1 ± 7.0 | − 1.0 (− 2.5, 0.6) mmHg | 0.21 |
| Antihypertensive drug summary measuresa | Baseline | 3 months | 6 months | 1 year | 2 years | 3 years | Annual change (95% CI) | p value |
|---|---|---|---|---|---|---|---|---|
| (N = 20) | (N = 20) | (N = 20) | (N = 20) | (N = 20) | (N = 19) | |||
| Number of DDDs, mean ± SD | 2.7 ± 1.6 | 2.5 ± 1.4 | 2.7 ± 1.5 | 2.7 ± 1.6 | 2.5 ± 1.2 | 2.4 ± 1.6 | − 3.5% (− 13.3%, 7.6%) | 0.52 |
| Number of antihypertensive drugs, median [25th–75th percentiles] | 2.0 [2.0–3.0] | 2.0 [1.8–3.0] | 2.0 [2.0–3.0] | 2.0 [1.8–3.0] | 2.0 [1.8–2.3] | 2.0 [1.0–3.0] | − 1.9% (− 12.8%, 10.5%) | 0.76 |
DBP diastolic blood pressure, DDD defined daily dosage, SBP systolic blood pressure, SD standard deviation
aBetablockers were excluded from the antihypertensive drug burden calculation as they were included in the antiarrhythmic drug burden