Table 2.
Selected MHC class-I allele, MHC class-II, and B cell binding peptides with their antigenicity scores and immunogenicity score to construct MESV
| Protein | Peptide | Allele | Antigenicity | Immunogenicity |
|---|---|---|---|---|
| MHC class-1 prM | YGVENVRVAY (187–196) |
HLA-A*29:02 HLA-A*30:02 HLA-B*15:01 HLA-B*35:01 HLA-B*46:01 HLA-C*12:03 |
1.5 | 0.25 |
| prM | FAVTALTIAY (252–261) |
HLA-A*01:01 HLA-A*26:01 HLA-A*29:02 HLA-A*80:01 HLA-B*15:01 HLA-B*35:01 HLA-B*46:01 HLA-B*53:01 HLA-B*58:01 HLA-C*12:03 |
1.2 | 0.25 |
| prM | LLVLAVGPAY (275–284) |
HLA-A*26:01 HLA-A*29:02 HLA-A*30:02 HLA-B*15:01 HLA-B*15:02 HLA-B*35:01 |
0.7 | 0.12 |
| E | GSQEVEFIGY (451–460) |
HLA-A*01:01 HLA-A*30:02 |
1.1 | 0.44 |
| E | QTAVDFGNSY (470–470) |
HLA-A*01:01 HLA-A*25:01 HLA-A*26:01 HLA-A*30:02 HLA-B*15:01 |
1.1 | 0.11 |
| MHC class-2 (E protein) | QTKIQYVIRAQLHVG (417–431) |
HLA-DRB1*03:06 HLA-DRB1*08:01 HLA-DRB1*08:13 HLA-DRB1*08:17 HLA-DRB1*11:04 HLA-DRB1*11:20 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*15:02 |
0.9 | 0.13 |
| E | TKIQYVIRAQLHVGA (418–432) |
HLA-DRB1*03:06 HLA-DRB1*04:21 HLA-DRB1*07:01 HLA-DRB1*07:03 HLA-DRB1*08:13 HLA-DRB1*08:17 HLA-DRB1*11:20 HLA-DRB1*11:28 HLA-DRB1*13:05 |
0.9 | 0.14 |
| E | PPHAATIRVLALGNQ (521–535) |
HLA-DRB1*08:06 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 |
0.8 | 0.38 |
| E | PHAATIRVLALGNQE (522–536) |
HLA-DRB1*11:04 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 |
0.8 | 0.28 |
| E | AATIRVLALGNQEGS (524–538) |
HLADRB1*11:04 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 |
0.8 | 0.9 |
| E | ATIRVLALGNQEGSL (525–539) |
HLA-DRB1*11:06 HLA-DRB1*11:14 HLA-DRB1*13:07 HLA-DRB1*13:11 |
0.8 | 0.9 |
| E | GAVLIWVGINTRNMT (743–757) |
HLA-DRB1*03:09 HLA-DRB1*04:08 HLA-DRB1*08:17 HLA-DRB1*11:02 HLA-DRB1*11:04 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB1*15:02 |
1 | 0.52 |
| E | AVLIWVGINTRNMTM (744–758) |
HLA-DRB1*04:08 HLA-DRB1*04:21 HLA-DRB1*08:06 HLA-DRB1*11:02 HLA-DRB1*11:14 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB1*15:02 HLA-DRB5*01:05 |
1.1 | 0.49 |
| E | VLIWVGINTRNMTMS (745–759) |
HLA-DRB1*04:08 HLA-DRB1*04:21 HLA-DRB1*08:06 HLA-DRB1*08:17 HLA-DRB1*11:02 HLA-DRB1*11:14 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB5*01:01 |
1.2 | 0.30 |
| B cell | HCIGITDRDFIEGVHG (287–302) | – | 1.2 | 0.76 |
| NCPNLSPREEPDDI (169–182) | – | 1.4 | 0.07 | |
| KVCYNAVLTHVKINDK (343–354) | – | 1.1 | 0.07 | |
| AVMGDTAWDFSSAGGF (696–711) | – | 1.0 | 0.18 | |
| VLIWVGINTRNMTMSM(745–760) | – | 1.2 | 0.16 |