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. 2023 Dec 5;13:21431. doi: 10.1038/s41598-023-48558-8

Table 3.

Adjusted hazard ratios of 5-year surgical complications after midurethral sling surgery, stratified by subgroups of age and diabetes mellitus.

Available N No. of events HR (95% CI)
Age ≤ 65 years
Diabetes mellitus
No 1429 50 Ref
Yes 94 5 1.793 (0.669, 4.807)
Surgical duration (h) 1523 55 1.111 (0.912, 1.355)
Menopausal syndrome diagnosis
No 1389 45 Ref
Yes 134 10 2.222 (0.982, 5.029)
Hormone replacement therapy
No 1360 42 Ref
Yes 163 13 1.384 (0.596, 3.215)
Average flow rate (ml/s) 1423 55 0.929 (0.853, 1.012)
TVT-O sling type
TOT 475 12 Ref
TVT-O 885 32 1.235 (0.598, 2.547)
Age > 65 years
Diabetes mellitus
No 354 30 Ref
Yes 84 8 1.185 (0.476, 2.952)
Surgical duration (h) 438 38 0.966 (0.697, 1.338)
Menopausal syndrome diagnosis
No 378 33 Ref
Yes 60 5 0.618 (0.146, 2.618)
Hormone replacement therapy
No 316 21 Ref
Yes 122 17 2.131 (0.880, 5.163)
Average flow rate (ml/s) 423 35 1.036 (0.893, 1.201)
TVT-O sling type
TOT 145 7 Ref
TVT-O 253 23 1.392 (0.516, 3.754)
Diabetes mellitus
Age (year) 178 13 1.013 (0.959, 1.069)
Surgical duration (h) 178 13 1.630 (0.971, 2.735)
Menopausal syndrome diagnosis
No 162 12 Ref
Yes 16 1 0.000 (0.000, 0.000)
Hormone replacement therapy
No 143 10 Ref
Yes 35 3 0.340 (0.036, 3.207)
Average flow rate (ml/s) 170 12 1.049 (0.923, 1.193)
TVT-O sling type
TOT 83 4 Ref
TVT-O 87 8 1.249 (0.400, 3.895)
Non-diabetes mellitus
Age (year) 1783 80 1.015 (0.989, 1.041)
Surgical duration (h) 1783 80 1.023 (0.847, 1.235)
Menopausal syndrome diagnosis
No 1605 66 Ref
Yes 178 14 1.504 (0.743, 3.046)
Hormone replacement therapy
No 1533 53 Ref
Yes 250 27 2.239 (1.235, 4.057)*,a
Average flow rate (ml/s) 1676 78 0.940 (0.860, 1.028)
TVT-O sling type
TOT 537 15 Ref
TVT-O 1051 47 1.191 (0.611, 2.321)

CI, confidence interval; HR, hazard ratio; TOT, transobturator tape; TVT-O, tension-free vaginal tape-obturator.

*Statistically significant.

aP for interaction with hormone replacement therapy was 0.0807.