Fig. 1. Schematic representation of tyrosine kinase inhibitors (TKIs) and the receptors they target.
Ang 2- Angiopoietin 2; Flt- fms like tyrosine kinase; KDR-Kinase insert domain receptor;PDGF-Platelet derived growth factor; PDGFR- Platelet derived growth factor receptor; PIGF- Placenta growth factor;VEGF- Vascular endothelial growth factor; VEGFR- Vascular endothelial growth factor receptor.