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. 2023 Dec 5;14:8042. doi: 10.1038/s41467-023-43798-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic for distribution and kinetics analysis of 8-9D mRNA after injection. C57BL/6 mice were i.v. injected with 5 μg of 8-9D mRNA with Lung-LNPs or Liver-LNPs as the delivery system. The animals (n = 5) were euthanized at 24 h post injection. b–e The sera (b), BALF (c), livers (d), and lungs (e) were collected for 8-9D detection by ELISA. 8-9D kinetics levels in BALF (f) and lungs (g) were further measured for the samples (n = 3) collected on day 2, 4, 8, 15, and 21 post injection. IL-6, TNF-α and IL-1β levels in sera at 1 day, 2 days, 4 days, and 8 days post injection of Lung-LNPs@mRNA^8-9D (h–j). Data are presented as mean ± SD and representative of two independent experiments with similar results. P values were determined by one-way ANOVA with Tukey’s multiple comparison post-hoc test. Source data are provided as a Source data file.