Fig. 4. Manhattan plots from the exome-wide association studies (EWAS).

A Manhattan plot of -log₁₀ p-values from an age-adjusted logistic regression, with 451 cases and 292 controls. B Manhattan plot of -log₁₀ p-values from an age-adjusted logistic regression for high grade prostate cancer (ISUP 3-5) cases (N = 203) against low risk or no PCa (N = 540). Known risk variants (N = 9) from the recently described set of 278 variants¹⁶ are shown as red circles, and known cancer variants as summarised previously¹³ are shown as orange circles, while variants in both datasets are represented in red triangles. Variants labelled in a white box indicate the overlapping gene, while those labelled in grey are the closest genes.