Fig. 3.

Gut microbiome structure in the experimental mice fed CD or WD. A and B: Three-dimensional principal coordinate analysis was performed with gut bacterial OUTs obtained from fecal samples of animals in separated housing (A) or cohousing (B) using unweighted UniFrac beta-diversity. C and D: Alpha-diversity was assessed with the obtained OTUs using Faith’s phylogenetic diversity analysis (Faith’s PD) in animals housed in separate cages (C) or cohoused cages (D). E: Ratios of Firmicutes to Bacteriodetes based on 16S rRNA gene sequencing data were plotted with average ± SEM (n = 3–4).