Fig. 5.

Metabolic features in Shp^−/− mice generated from heterozygous breeding scheme. A: Their body weights upon WD regimen were monitored, and the average values were plotted with SEM (left). Their fat masses were assessed using EchoMRI one day before euthanasia for tissue collection (right). The average values were presented with SEM. n = 8–10. B: Hepatic TG levels were presented as means ± SEM. n = 5–6. C: Serum ALT levels were assessed, and their average values were presented with SEM. n = 6–7. D: mRNA levels of indicated hepatic inflammatory and fibrogenic genes were quantified, and their mean values were plotted with SEM (n = 6–8). Two-way ANOVA and Student's t-test were performed to evaluate statistical significance. #comparison with CD, ∗comparison with WT counterparts. Three symbols represent P < 0.005, two symbols P < 0.01, and one symbol P < 0.05.