Fig. 9.

BA compositions in GBs of cohoused littermate animals. A: BA composition was determined in GBs of cohoused WT and Shp^−/− mice fed CD or WD. Their absolute concentrations were converted to percent values to be compared with values obtained from separately grouped animals in Fig. 2A. The average percent values of each BA species were presented as stacked bar graphs (n = WTCD [6], SHPKOCD [3], WTWD [6], and SHPKOWD [5]). B: Average concentrations of three major tauro-conjugated BAs were plotted with SEM values. Two-way ANOVA was performed to measure statistical significance. Student's t-test was also performed to compare two corresponding groups. #P < 0.05 compared with CD counterpart, ∗∗P < 0.01 compared with WT counterpart.