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. 2023 Dec 5;14:8051. doi: 10.1038/s41467-023-43904-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Chest CT from monkey #7 (S315 + RNP) from (b) below. Arrows highlight areas of consolidation. b Correlation between regional editing efficiency or regional DRI-NLS-Cy5 nuclear localization and areas of consolidation on CT scan. Regions studied include RUL - right upper lobe, RML - right middle lobe, RLL - right lower lobe, LUL-Cr - left upper lobe, cranial part, LUL Ca - left upper lobe, caudal part, LLL - left lower lobe. The CT scans were scored in a blinded fashion for changes in aeration as follows: NC: no change from baseline; + subtle nonsegmental consolidation; ++ segmental consolidation; +++ dense consolidation. Filled circles represent editing efficiencies for indicated region as shown in Fig. 4c. Source data are provided as a Source Data File.