Table 3.

Classification performances of the system and the ophthalmologists on validation datasets 1 and 2.

	Sensitivity (95% CI)		Specificity (95% CI)		AUC (95% CI)		P-value
	Set 1	Set 2	Set 1	Set 2	Set 1	Set 2	Set 1	Set 2
Grader 1	0.788 (0.773–0.802)	0.794 (0.785–0.803)	0.975 (0.969–0.980)	0.983 (0.980–0.986)	N/A	N/A	8.43e–9	9.04e–39
Grader 2	0.928 (0.918–0.937)	0.603 (0.592–0.614)	0.977 (0.971–0.982)	0.968 (0.983–0.988)	N/A	N/A	1.18e–4	9.04e–39
AI Model	0.918 (0.908–0.927)	0.914 (0.907–0.920)	0.934 (0.925–0.942)	0.922 (0.916–0.928)	0.952 (0.945–0.968)	0.966 (0.959–0.974)

AUC area under the curve, CI confidence interval, AI artificial intelligence, Set 1: validation dataset 1, Set 2: validation dataset 2, N/A not available.