Table 4.
Evaluation of the generalization capability of the algorithm on images with/without the features of some retinal comorbidities such as DR and AMD on validation dataset 1 and validation dataset 2.
| Sensitivity (95% CI) | Specificity (95% CI) | AUC (95% CI) | P-value | |||||
|---|---|---|---|---|---|---|---|---|
| Set 1 | Set 2 | Set 1 | Set 2 | Set 1 | Set 2 | Set 1 | Set 2 | |
| With Comorbidities | 1.000 (1.000–1.000) | 0.922 (0.916–0.928) | 0.825 (0.811–0.838) | 0.939 (0.933–0.944) | 0.970 (0.954–0.987) | 0.975 (0.964–0.985) | 4.55e–11 | 1.97e–6 |
| Without Comorbidities | 0.893 (0.882–0.903) | 0.912 (0.905–0.918) | 0.944 (0.935–0.952) | 0.913 (0.906–0.919) | 0.943 (0.922–0.965) | 0.963 (0.954–0.972) | ||
| Overall Performance | 0.918 (0.908–0.927) | 0.914 (0.907–0.920) | 0.934 (0.925–0.942) | 0.922 (0.916–0.928) | 0.952 (0.945–0.968) | 0.966 (0.959–0.974) | ||
DR diabetic retinopathy, AMD age-related macular degeneration, AUC area under the curve, CI confidence interval, Set 1: validation dataset 1, Set 2: validation dataset 2.